Publications by authors named "Anna Schwager Karpukhina"

The most common form of facioscapulohumeral dystrophy (FSHD1) is caused by a partial loss of the D4Z4 macrosatellite repeat array in the subtelomeric region of chromosome 4. Patients with FSHD1 typically carry 1 to 10 D4Z4 repeats, whereas nonaffected individuals have 11 to 150 repeats. The ~150-kilobyte subtelomeric region of the chromosome 10q exhibits a ~99% sequence identity to the 4q, including the D4Z4 array.

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Article Synopsis
  • * The study examined how the HIV-1 Tat protein affects B cell function, revealing that it disrupts the expression of many genes, particularly those related to the immune system, like MHC class II genes.
  • * The interference caused by Tat on HLA-DR expression impairs the immune response against EBV, potentially leading to increased susceptibility to B cell malignancies in HIV-positive individuals.
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