Publications by authors named "Anna Sanyiwa"
Purpose: Primary open-angle glaucoma (POAG) has been reported to occur more frequently in Africans, and to follow a more severe course compared to Europeans. We aimed to describe characteristics of POAG presentation and treatment across three ethnic groups from Africa and one from Europe.
Methods: We ascertained 151 POAG patients from South African Coloured (SAC) and 94 South African Black (SAB) ethnicity from a university hospital in South Africa.
Purpose: To investigate the distribution of corneal spherical aberration (SA) in Tanzanian people of African descent, and to examine the correlation between corneal SA and ocular parameters.
Design: Cross-sectional population-based study.
Methods: Residents aged 40 years and older in three villages in the Mkuranga district in Tanzania were enlisted as study participants.
Hypertensive retinopathy is a known marker of cardiovascular disease, and among unselected patients with chronic kidney disease (CKD) more severe retinopathy has been associated with lower estimated glomerular filtration rate (eGFR). This association has, however, not been widely studied among nondiabetic hypertensive patients with CKD, especially in sub-Saharan Africa. We aimed to determine the prevalence and severity of hypertensive retinopathy and its relationship with eGFR among nondiabetic CKD patients seen at Muhimbili National Hospital in Dar es Salaam, Tanzania.
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- Primary open angle glaucoma (POAG) has a significant genetic component and shows varying prevalence among ethnic groups, being notably more common in black African populations.
- A genome-wide association study involving Tanzanian, South African, and African American samples identified a confirmed association with the TXNRD2 gene and revealed a genetic risk score linked to 15 previously known POAG loci.
- Additionally, a novel genetic locus associated with POAG was identified (EXOC4), but efforts to validate this finding in West African populations faced challenges due to genetic diversity, indicating the need for larger studies to better understand POAG in these groups.
Bilateral optic neuropathy in Dar es Salaam is now considered endemic and is estimated to affect 0.3-2.4% of young adults.
View Article and Find Full Text PDFObjective: The purpose of this study was to assess glycemic control and complications of type 1 diabetes in children and adolescents in Tanzania.
Research Design And Methods: This demographic and clinical survey included 99 children aged between 5 and 18 years attending Muhimbili National Hospital Clinic for Diabetes. A structured questionnaire was used for evaluating socioeconomic data and for estimation of the prevalence of acute complications occurring over the last 6 months.