Publications by authors named "Anna Sanchez Jimenez"
Article Synopsis
- The Notch signaling pathway is crucial for cellular differentiation and is influenced by chromatin structure, with focus on the antagonist Hairless and its interaction with the histone chaperone Asf1.
- A new allele was engineered that shows Hairless behaving as a gain of function, suggesting it has a role in regulating Notch gene activity under certain biological conditions.
- Contrary to previous expectations, increasing Asf1 levels enhances Hairless's repressive activity in eye development, demonstrating the intricate relationship between Notch regulators and chromatin modifiers.
The recent emergence of multiple SARS-CoV-2 variants has caused considerable concern due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It is, therefore, paramount to develop therapeutic strategies that inhibit all known and future SARS-CoV-2 variants. Here, we report that all SARS-CoV-2 variants analyzed, including variants of concern (VOC) Alpha, Beta, Gamma, Delta, and Omicron, exhibit enhanced binding affinity to clinical grade and phase 2 tested recombinant human soluble ACE2 (APN01).
View Article and Find Full Text PDFThe recent emergence of multiple SARS-CoV-2 variants has caused considerable concern due to reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It is therefore paramount to develop therapeutic strategies that inhibit all known and future SARS-CoV-2 variants. Here we report that all SARS-CoV-2 variants analyzed, including variants of concern (VOC) Alpha, Beta, Gamma, and Delta, exhibit enhanced binding affinity to clinical grade and phase 2 tested recombinant human soluble ACE2 (APN01).
View Article and Find Full Text PDF