Publications by authors named "Anna S Ryabova"
Russian Snow White (RSW) chickens are characterized by high egg production, extreme resistance to low temperatures, disease resistance, and by the snow-white color of the day-old chicks. Studying the genome of this unique chicken breed will reveal its evolutionary history and help to understand the molecular genetic mechanisms underlying the unique characteristics of this breed, which will open new breeding opportunities and support future studies. We have sequenced and made a de novo assembly of the whole RSW genome using deep sequencing (250×) by the short reads.
View Article and Find Full Text PDFCreating a complete picture of the regulation of transcription seems to be an urgent task of modern biology. Regulation of transcription is a complex process carried out by transcription factors (TFs) and auxiliary proteins. Over the past decade, ChIP-Seq has become the most common experimental technology studying genome-wide interactions between TFs and DNA.
View Article and Find Full Text PDFArticle Synopsis
- ChIP-Seq is a key technology for studying protein-DNA interactions, with databases like ENCODE and ChIP-Atlas compiling extensive datasets for researchers.
- The authors introduced two new quality control metrics to better estimate the accuracy of ChIP-Seq datasets, focusing on reducing false positives and negatives.
- These metrics assist in evaluating dataset quality and comparing different peak calling methods, and they've been turned into a tool available on the BioUML platform for easier access and analysis.