Biological Significance of Glutathione S-Transferases in Human Sperm Cells.

Background: Oxidative stress is considered as one of the causes of male subfertility or infertility. Among antioxidant enzymes, the crucial role belongs to glutathione -transferases (GSTs). Data on the biological role of GSTs in the defense mechanisms of sperm cells in fertile and infertile men are limited.

Alterations in Arginase-NO-synthase System of Spermatozoa in Human Subjects with Different Fertility Potential.

Background: Infertility is an important worldwide problem which affects 10-15% of couples globally. Altered NO production has also been implicated in the pathogenesis of the male infertility. The present study was designed to evaluate the changes in the activity of NO-synthase (NOS) and arginase in spermatozoa of patients with infertility.