Publications by authors named "Anna Ruszczak"

Article Synopsis
  • Pharmacotherapy successfully controls seizures in about 70% of epilepsy patients, but 30% still face treatment resistance, highlighting a need for effective therapies.
  • Our research involved mouse models with varying levels of opioid system activity, revealing that mice with low activity experienced more intense and quicker seizures when exposed to pentylenetetrazole (PTZ) than those with high activity.
  • We found that using an opioid receptor antagonist (naloxone) alongside a GABA receptor agonist (diazepam) can significantly reduce the required dose of diazepam, offering a promising strategy to minimize addiction risk while managing seizures.
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Mammary tumors are the second most common neoplasia in dogs. Due to the high similarity of canine mammary tumors (CMT) to human breast cancers (HBC), human biomarkers of HBC are also detectable in cases of CMT. The evaluation of biomarkers enables clinical diagnoses, treatment options and prognosis for bitches suffering from this disease.

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Article Synopsis
  • The study aimed to explore how aglepristone affects the ovaries and uterus of non-pregnant bitches, focusing on steroid hormone levels and receptor expression during placentation.
  • Fourteen bitches received either aglepristone or saline, and their hormonal levels were checked while their reproductive tissues were analyzed for structural changes and receptor activity.
  • Results indicated lower progesterone levels due to aglepristone, alongside increased estrogen receptor expression in the endometrium, which was linked to inflammation and thicker uterine tissues compared to the control group.
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The Department of Health and Social Care of the Municipal Council in Poznań initiated a programme of prophylaxis against tuberculosis in the homeless. The study involves those homeless people who are registered in Poznań-based homeless shelters and temporary residential sites. Chest x-ray was performed in 403 homeless and 57 persons of staff.

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