Publications by authors named "Anna Rozenblit"
Article Synopsis
- Mycobacterium abscessus is a significant emerging pathogen linked to severe lung infections, particularly manifesting as a "Rough" phenotype in clinical settings, which may indicate heightened virulence.
- The study investigated the transmissibility of a GPL-defective (Rough) strain compared to its parent (Smooth) strain using various survival assays on surfaces and in disinfectants, finding no survival advantage for either phenotype.
- Results indicate that while certain evolutionary changes impact transmission fitness, the GPL defect alone does not solely account for the reduced transmissibility of these clinical strains, suggesting the need for further investigation into other mutations.
Background: Tolerance to antibiotics and persistence are associated with antibiotic treatment failures, chronic-relapsing infections, and emerging antibiotic resistance in various bacteria, including Staphylococcus aureus. Mechanisms of persistence are largely unknown, yet have been linked to physiology under low-ATP conditions and the metabolic-inactive state. EttA is an ATP-binding cassette protein, linked in Eschrechia coli to ribosomal hibernation and fitness in stationary growth phase, yet its role in S.
View Article and Find Full Text PDF