Publications by authors named "Anna Rosa Marra"
Introduction: The purpose of TheShinISS-Vax|Flu study is to examine the association between influenza vaccines and adverse events requiring hospital admission or emergency care during the influenza vaccination campaigns 2021/2022 and 2022/2023 in Italy.
Methods And Analysis: This is a Self-Controlled Case Series multiregional study using linked routinely collected data from regional healthcare databases of the participating regions. Study participants will be persons aged ≥6 months, unvaccinated or who have received influenza vaccine during the influenza vaccination campaigns in the seasons 2021/2022 and 2022/2023 in Italy and who have experienced the outcome of interest for the first time during the study period (1 September 2021-30 June 2022 and 1 September 2022-30 June 2023 for the first and second vaccination campaigns, respectively).
Postmarketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12 to 39 years in Italy: A multi-database, self-controlled case series study.
PLoS Med
July 2022
Background: Myocarditis and pericarditis following the Coronavirus Disease 2019 (COVID-19) mRNA vaccines administration have been reported, but their frequency is still uncertain in the younger population. This study investigated the association between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA vaccines, BNT162b2, and mRNA-1273 and myocarditis/pericarditis in the population of vaccinated persons aged 12 to 39 years in Italy.
Methods And Findings: We conducted a self-controlled case series study (SCCS) using national data on COVID-19 vaccination linked to emergency care/hospital discharge databases.
Article Synopsis
- A pharmacovigilance study analyzed reports of myocarditis and pericarditis associated with mRNA COVID-19 vaccines in the VAERS database from 1990 to July 2021, finding significant cases linked primarily to these vaccines.
- The majority of reported cases were in young males, particularly after the second vaccine dose, but the overall risk of these heart conditions was much lower compared to the risks from COVID-19 infection and common viral myocarditis.
- Compared to smallpox vaccines, the study found that mRNA COVID-19 vaccines had a significantly lower probability of causing myocarditis or pericarditis.