Publications by authors named "Anna Ritah Namuganga"
Article Synopsis
- The study addresses the need for biomarkers to improve tuberculosis treatment monitoring and shorten treatment durations.
- The researchers examined serum biomarkers in 53 active pulmonary TB patients to evaluate their ability to predict treatment response after 2 months.
- They found significant differences in certain biomarkers and identified a bio-signature that accurately predicted treatment outcomes, highlighting potential for future clinical trials and monitoring tools.
Background: There is a need for new tools for the diagnosis of tuberculosis (TB) amongst patients who present at primary health care centers with symptoms suggestive of TB.
Objectives: To assess the abilities of selected blood-based host biomarkers to discriminate between patients who self-presented with symptoms suggestive of TB and were subsequently diagnosed with pulmonary tuberculosis (PTB), other respiratory diseases (ORD) with latent Mycobacterium tuberculosis infection (ORD_LTBI) or ORD without latent infection (ORD_NoLTBI).
Methods: Presumptive TB patients (n = 161) were enrolled at a TB Clinic in Kampala, Uganda, and blood was collected.
Past and Present Approaches to Diagnosis of Active Pulmonary Tuberculosis.
Front Med (Lausanne)
September 2021
Tuberculosis disease continues to contribute to the mortality burden globally. Due to the several shortcomings of the available diagnostic methods, tuberculosis disease continues to spread. The difficulty to obtain sputum among the very ill patients and the children also affects the quick diagnosis of tuberculosis disease.
View Article and Find Full Text PDFWe investigated host-derived biomarkers that were previously identified in QuantiFERON supernatants, in a large pan-African study. We recruited individuals presenting with symptoms of pulmonary TB at seven peripheral healthcare facilities in six African countries, prior to assessment for TB disease. We then evaluated the concentrations of 12 biomarkers in stored QuantiFERON supernatants using the Luminex platform.
View Article and Find Full Text PDFBackground: In the search for fast, simple and better ways for diagnosis of tuberculosis (TB), there is need to discover and evaluate new biomarkers that are found in samples other than sputum to determine their effectiveness. This study examined the utility of saliva vis-a-vis serum by evaluating levels of biomarkers found in saliva and serum from TB suspects.
Methods: Study enrolled tuberculosis suspects.