Publications by authors named "Anna Rastorgueva"
Background: Tracking the migration pathways of living cells after their introduction into a patient's body is a topical issue in the field of cell therapy. Questions related to studying the possibility of long-term intravital biodistribution of mesenchymal stromal cells in the body currently remain open.
Methods: Forty-nine laboratory animals were used in the study.
Background: Radiation therapy (RT) is an important step in the treatment of primary breast cancer as it is one of the leading contributors to cancer incidence among women. Most patients with this disease acquire radiation-induced lymphopenia in the early post-radiation period; however, little is known about the effect of RT on the composition of lymphocyte populations in such patients. This study was aimed at investigating the effect of adjuvant remote RT-performed in the classical mode for patients with primary breast cancer-on the main components of cell-mediated immunity (major lymphocyte populations), including those in patients receiving chemotherapy.
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- Individuals encounter low doses of ionizing radiation (LDIR) throughout their lives, making it crucial to understand the associated risks, particularly regarding mesenchymal stromal cells (MSCs) which are important for regeneration.
- Human connective gingiva MSCs (hG-MSCs) were subjected to varying LDIR levels (50 to 1000 mGy) and their behavior was analyzed for 64 days post-irradiation, focusing on secretory profiles and cell characteristics.
- Initially, LDIR stimulated MSCs, but over time, the low doses led to reduced functional activity, similar to that seen with higher doses, indicating potential long-term risks of LDIR exposure.
Background: The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin.
Methods: We used 80 animals, randomly assigned to four groups: control (C) animals that did not receive therapy; control with the introduction of culture medium concentrate (CM); introduction of MSCs (PL); introduction of CMPL. LRI modeling was performed on an X-ray machine at a dose of 110 Gy.