The prognostic value of retinal vessel analysis in primary open-angle glaucoma.

Purpose: To analyse a prognostic value of initial retinal vessel flicker response for the 3-year development of functional (visual field) and morphological (nerve fibre layer thickness) damage progression in primary open-angle glaucoma patients.

Patients And Methods: Initially, 70 patients were recruited, and flicker response was measured by standardized procedure with the retinal vessel analyser (RVA). Ocular coherence tomography of retinal nerve fibre layer (OCT RNFL) and a visual field testing were performed at beginning and every 6 months for 3 years; 56 patients completed the study.

Cognitive dysfunction after on-pump operations: neuropsychological characteristics and optimal core battery of tests.

Postoperative cognitive dysfunction (POCD) is a mild form of perioperative ischemic brain injury, which emerges as memory decline, decreased attention, and decreased concentration during several months, or even years, after surgery. Here we present results of our three neuropsychological studies, which overall included 145 patients after on-pump operations. We found that the auditory memory span test (digit span) was more effective as a tool for registration of POCD, in comparison with the word-list learning and story-learning tests.

Steroid myopathy in patients with chronic respiratory diseases.

Background: Corticosteroid-induced myopathy is a well known clinical entity, and experimental studies showed decreased rate of protein synthesis and increased rate of protein breakdown in muscles of chronically treated animals.

Objective: The present observational study was aimed to evaluate skeletal muscle functions in asthmatics and patients with other chronic respiratory diseases treated by inhaled or oral corticosteroids.

Methods: Thirty six patients with respiratory diseases were included into the study.

Effect of ageing on the retinal vascular responsiveness to flicker light in glaucoma patients and in ocular hypertension.

Aim: To evaluate the effect of ageing on the retinal vascular responsiveness to flicker light in glaucoma and ocular hypertension (OHT).

Methods: Retinal vascular response to flicker was measured with the retinal vessel analyser in 56 healthy subjects (59 ± 9 years), 50 primary open-angle glaucoma (POAG) (60 ± 10 years) and 46 OHT patients (62 ± 9 years). In the glaucoma group, the less damaged eye; in the OHT group, the eye with the higher intraocular pressure; and in healthy controls, one randomly selected eye was considered.

Neuropsychological Functions of μ- and δ-Opioid Systems.

Brain opioid innervation is involved in many pathophysiological processes related to drug addiction. The main idea of the present review is that μ-/δ-opioid innervation is an intrinsic component of the motor/approach behavior network, which is activated synergetically with dopaminergic mesocorticolimbic network. Contribution of opioid innervation to the motor/approach behavior processing includes generation of positive emotions and inhibition of pain and stress reactions in order that the individual would be able to reach the vital goal.

Function and morphology in macular retinoschisis associated with optic disc pit in a child before and after its spontaneous resolution.

Optic disc pit (ODP) is a rare congenital defect within the optic nerve head. Macula elevation associated with ODP develops in 75-93% of the adult patients. Macular involvement in children with optic disc pit is rare, and only a few cases have been published to date.

Association between risk factors and glaucomatous damage in untreated primary open-angle glaucoma.

Purpose: To analyze an association between the presumed risk factors for glaucoma and the actual extent of glaucomatous damage in untreated primary open-angle glaucoma.

Patients And Methods: In 50 untreated open-angle glaucoma patients, we analyzed an association between the level of glaucomatous damage and presumed glaucoma risk factors: mean untreated intraocular pressure (IOP) and short-term IOP variability, ocular pulse amplitude, corneal thickness, acral and corneal temperature, retinal arterial diameter and retinal venous diameter, choroidal blood flow (laser Doppler flowmetry flow, velocity, volume), heart rate, and ocular perfusion pressure. Morphologic damage (mean retinal nerve fiber layer thickness, measured by ocular coherence tomography) and functional damage (visual field mean defect) were evaluated separately in 2 forward-stepwise multiple regression models.

Choroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension.

Purpose: To analyze submacular choroidal blood flow (ChBF) response to isometric exercise in untreated patients with glaucoma and ocular hypertension.

Methods: ChBF was examined by means of confocal laser Doppler flowmetry during 5 minutes of baseline, during 90 seconds of isometric exercise with a Martin's vigorimeter and during 15 minutes of recovery. Values from one randomly chosen eye of 45 healthy subjects, the eye with more advanced damage in 45 primary open-angle glaucoma (POAG) patients, and the eye with higher native intraocular pressure in 45 patients with ocular hypertension (OHT) were acquired, and parameters of ChBF as well as blood pressure response were analyzed.

Electroencephalography as a tool for assessment of brain ischemic alterations after open heart operations.

Cardiac surgery is commonly associated with brain ischemia. Few studies addressed brain electric activity changes after on-pump operations. Eyes closed EEG was performed in 22 patients (mean age: 45.

Size of left cardiac chambers correlates with cerebral microembolic load in open heart operations.

Background. Microemboli are a widely recognized etiological factor of cerebral complications in cardiac surgery patients. The present study was aimed to determine if size of left cardiac chambers relates to cerebral microembolic load in open heart operations.

Alexithymia, depression and heart rate in candidates for cardiac surgery.

Effects of psychological traits on heart rate (HR) and heart rate variability (HRV) were evaluated in patients awaiting cardiac surgery. Alexithymics demonstrated slowed HR, whereas high cognitive performance was associated with elevated HR in 2-3 days before surgery. Depression negatively correlated with HRV low frequency power.

Asymmetric cerebral embolic load and postoperative cognitive dysfunction in cardiac surgery.

Background: The aim of the study was to determine the effects of asymmetric cerebral embolic load on cognitive functions.

Methods: Thirty-six open heart surgery (OH) and 26 coronary artery bypass grafting (CABG) patients were evaluated by neuropsychological and transcranial Doppler tests.

Results: OH was associated with a significantly larger microembolic load in comparison to CABG.

EEG correlates of Wechsler Adult Intelligence Scale.

It was recently shown that cognitive functions requiring more widespread brain integration relate to slower EEG activity, whereas cognitive performance supported by local brain integration is associated with faster EEG components (Von Stein & Sarnthein, 2000). Associations were studied between performance on WAIS and resting EEG spectral parameters in heroin abusers and normal young males. The most prominent associations between WAIS and EEG variables were consistently registered in polar and lateral frontal/temporal derivations.

Neural correlates of cognitive dysfunction after cardiac surgery.

Patients who underwent cardiac surgery and their relatives often complain on postoperative memory impairment. Most prospective neuropsychological studies also found postoperative cognitive decline early after surgery. Nevertheless, recently several reports questioned the existence of long-term brain alterations in these patient cohorts.

Heroin abusers' performance on the Tower of London Test relates to the baseline EEG alpha2 mean frequency shifts.

Planning function deficit is the most consistent finding in neuropsychological studies of heroin addicts. The performance on the Tower of London Test (TLT) correlated with the duration of daily heroin abuse (DDHA) in our previous study. Alpha2 mean frequency in anterior/central derivations was also predicted by DDHA in the same patient population.

EEG spectral power and mean frequencies in early heroin abstinence.

The purpose of the present study was to investigate cumulative heroin effects on brain functioning by studying relationships among electroencephalography (EEG) spectral power and mean frequencies and heroin abuse history. Eyes-closed resting EEG data were collected from the 19 monopolar electrode sites in 33 heroin abusers and 13 age-matched healthy volunteers. The mean age of the patients was 23.