Publications by authors named "Anna Paula Perin Vidigal"
Chlorpyrifos intermittent exposure enhances cardiovascular but not behavioural responses to contextual fear conditioning in adult rats: Possible involvement of brain oxidative-nitrosative stress.
Yuri Fernandes Pereira Rosa Gabriel Gavazza Noé Maria Gabriela Oliveira Merlo Raphael Rizzo Calixto Anna Paula Perin Vidigal
Behav Brain Res
February 2025
Article Synopsis
- Exposure to organophosphorus compounds, like chlorpyrifos (CPF), can lead to various health issues affecting the brain and heart, primarily due to the inhibition of the enzyme acetylcholinesterase (AChE).
- In a study on rats, intermittent CPF treatment was found to increase anxiety and impair motor functions, but it did not significantly affect depression symptoms or fear responses after a washout period.
- Measurement of AChE activity showed significant reductions in key brain areas, indicating a link between CPF exposure and neurotoxicity, particularly at higher doses.