Incidence and status of insulin secretion in pregnant women with flat plasma glucose profiles during oral glucose tolerance test.

Objectives: Flat shaped glucose curves (FC) during oral glucose tolerance test (OGTT) in pregnant women (PW) are a not uncommon finding. We aimed to define the FC incidence in a large PW cohort and to describe the status of insulin and C-peptide secretion in women with FC when compared with a well-matched control group.

Methods: 1050 PW performing OGTT for gestational diabetes screening were enrolled.

Wheat allergy: a double-blind, placebo-controlled study in adults.

Background: Wheat is believed to be an uncommon cause of food allergy in adults; the number of studies that address IgE mediated wheat allergy in adults is all too few.

Objective: Determine how many subjects with a history of wheat allergy have real allergy by double-blind, placebo-controlled food challenge; identify the symptoms manifested during the challenge; determine the lowest provocation dose; determine the performance characteristics of wheat skin prick test and specific IgE; identify subjects with real wheat allergy for potential immunoblotting studies.

Methods: Patients underwent skin test with commercial wheat extract; specific wheat IgE was determined.