Publications by authors named "Anna Olomi"
Endometrial cancer is one of the most common gynecological malignancies, and while early-stage cases are highly treatable, recurrent or advanced EC remains challenging to manage. Immunotherapy, particularly immune checkpoint inhibitors, has revolutionized treatment approaches in oncology, and its application in EC has shown promising results. Key to immunotherapy efficacy in EC is the tumor's mismatch repair status, with MMR-deficient tumors demonstrating a higher tumor mutational burden and increased PD-L1 expression, making them more susceptible to immune checkpoint inhibitors (ICIs) such as pembrolizumab, durvalumab, and dostarlimab.
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- The Sprouty genes (Spry1-4) inhibit receptor tyrosine kinases and play important roles in embryo development and tumor suppression in adults.* -
- Research involving adult-onset triple knockout mice for Spry1, Spry2, and Spry4 shows that while these mice experience various health issues, like weight loss and endocrine abnormalities, they do not have an increased incidence of tumors compared to normal mice.* -
- Findings suggest that the loss of Sprouty genes may impact metabolic and endocrine functions without necessarily leading to tumor development.*
Genes of the Sprouty family (Spry1-4) restrain signaling by certain receptor tyrosine kinases. Consequently, these genes participate in several developmental processes and function as tumor suppressors in adult life. Despite these important roles, the biology of this family of genes still remains obscure.
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