Household, dietary, and clinical characteristics of childhood caries and overweight progression-A prospective cohort study.

Background: Childhood caries and obesity are complex chronic diseases with negative health outcomes.

Aim: This study sought a risk profile for childhood caries and overweight.

Design: Children were recruited into a longitudinal prospective cohort study.

MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation.

The epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 lineage has recently become a leading cause of hospital-associated bloodstream infections (BSIs). Here, we leveraged this recent introduction into hospitals and the limited genetic variation across USA300 isolates to identify mutations that contribute to its success in a new environment. We found that USA300 BSI isolates exhibit altered virulence regulation.