Regional COVID-19 measures and effects on subjective well-being in Germany: observing trends over time with data from a large population survey.

Background: COVID-19 measures in Germany varied during the pandemic, and it seems natural that in addition to factors such as incidence, health system capacity, etc., these interventions and their social and economic consequences had an impact on the evolution of the population's well-being. Since the beginning of the pandemic, there has been a suspicion that the health burden would fall mainly on population groups with a lower socio-economic status, and that COVID-19, including the policy measures, could therefore contribute to increasing social inequalities in health.

[Review of selected methods for estimating risk from occupational exposure to carcinogenic substances].

Assessing the expected level of cancer risk associated with occupational exposure to chemical substances is extremely important, as it forms the basis for the proper and safe organization of work in a company. It allows the translation of scientific research findings into legal regulations, enabling the implementation of appropriate preventive measures and optimizing the protection of workers' health. This article discusses various methods for estimating the risk associated with the occurrence of cancer due to exposure to carcinogenic substances in workplaces.

Assessment of in vitro skin permeation and accumulation of phenolic acids from honey and honey-based pharmaceutical formulations.

Background: Honey has been successfully used in wound care and cosmetics because of its effective biological properties, including antibacterial, antioxidant, and anti-inflammatory activities. Polyphenols, particularly phenolic acids, are key honey components responsible for these beneficial effects. In recent years, there has been a growing demand for natural, ecologically friendly, and biodegradable products in the modern cosmetics and wound care market.

Innovative approaches to enhancing kombucha through flavour additives: a phytochemical and antioxidant analysis.

This study aimed to determine the phytochemical profile (flavonoids, phenolic acids, caffeine, vitamin C, and acetic acid), antioxidant potential (DPPH, ABTS, and FRAP method), total polyphenol (TPC) and flavonoid (TFC) content, as well as pH of eight commercial green tea-based kombuchas. The beverages were enriched with lemongrass; lavender; liquorice and mint; turmeric and lemon; mango; reishi and chaga; mint, rose, and pomegranate. The highest tested properties were found for kombucha with reishi and chaga (FRAP), with mint, rose, and pomegranate (ABTS), as well as with turmeric and lemon (DPPH, TPC, TFC).

Effect of Ginseng Supplementation on Exercise Endurance as a Support for Cardiovascular Disease Management: A Systematic Review and Meta-Analysis.

Ginseng has multi-directional pharmacological properties. Some data suggest that ginseng can enhance physical endurance, which, in turn, leads to protection of the cardiovascular system. However, not all experiments are conclusive.

Development of a brief screening measure of unmet supportive care needs (SCNS-P&C-6) in caregivers of people with high-grade glioma.

Purpose: Informal caregivers of people with high grade glioma (HGG) often have high levels of unmet support needs. Routine screening for unmet needs can facilitate appropriate and timely access to supportive care. We aimed to develop a brief screening tool for HGG caregiver unmet needs, based on the Supportive Care Needs Survey-Partners & Caregivers (SCNS-P&C).

Fractionated low-dose radiotherapy primes the tumor microenvironment for immunotherapy in a murine mesothelioma model.

Combination immune checkpoint inhibitors (nivolumab and ipilimumab) are currently a first-line treatment for mesothelioma; however, not all patients respond. The efficacy of treatment is influenced by the tumor microenvironment. Murine mesothelioma tumors were irritated with various radiotherapy doses.

Correlation of Preclinical Imaging Modalities and Immunohistochemistry for Tumor Hypoxia and Vasculature.

Background/aim: Tumors exhibit impaired blood flow and hypoxic areas, which can reduce the effectiveness of treatments. Characterizing these tumor features can inform treatment decisions, including the use of vasculature modulation therapies. Imaging provides insight into these characteristics, with techniques varying between clinical and preclinical settings.

Coupling of response biomarkers between tumor and peripheral blood in patients undergoing chemoimmunotherapy.

Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time course RNA sequencing (RNA-seq) of peripheral blood mononuclear cells with pre-treatment tumor transcriptome data from the single-arm, phase 2 DREAM trial (N = 54).

The Role of Light in Enhancing the Nutritional and Antioxidant Qualities of Basil, Mint and Lemon Balm.

Mint ( L.), basil, () and Melissa ( L.) are herbaceous plants from the family.

The interaction between non-coding RNAs and SGLT2: A review.

Sodium-glucose cotransporter 2 (SGLT2, SLC5A2) is a promising target for a new class of drug primarily established as kidney-targeting as well as emerging class of glucose-lowering drugs in diabetes. Studies showed that SGLT2 inhibitors also have a systemic impact via indirectly targeting the heart and kidneys which exerts broad cardio- and nephroprotective effects. Additionally, as cancer cells tightly require glucose supply, studies also questioned how SGLT2 inhibitors impact molecular pathology and cellular metabolism in cancer hallmarks.

Correction: Dulski et al. An Organic-Inorganic Hybrid Nanocomposite as a Potential New Biological Agent. 2020, , 2551.

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Comprehensive evaluation of ibuprofenate amino acid isopropyl esters: insights into antioxidant activity, cytocompatibility, and cyclooxygenase inhibitory potential.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain relief and inflammation management, but there are challenges related to poor solubility and bioavailability. We explored modifications of ibuprofen (IBU) by forming ionic pairs using amino acid alkyl esters to enhance solubility without compromising the ability to inhibit cyclooxygenase (COX)-1 and COX-2). We comprehensively evaluated the pharmacological properties of the IBU derivatives, focusing on antioxidant activity (based on the ability to scavenge DPPH and ABTS), biocompatibility (using human dermal fibroblasts), and COX inhibitory potential.

Characterization of naproxen salts with amino acid esters and their application in topical skin preparations.

In the study, the modification of naproxen (NAP) with esters of four amino acids (AAs): glycine (GlyOiPr), L-proline (ProOiPr), L-leucine (LeuOiPr), and L-serine (SerOiPr) isopropyl ester was performed to improve water solubility and enhance the permeation of the drug through the skin in comparison to the parent NAP. The NAP derivatives were prepared using the equimolar ratio of the components. In-depth NMR and FTIR analysis revealed that the salts formed with the proton transfer from the carboxylic group of NAP to the amine group of the appropriate AA ester.

L. ethanolic extracts and essential oil - chemical composition, antioxidant potential, antibacterial activity, and skin permeation study.

Introduction: L. is classified as a medicinal plant and used in traditional medicine. The root of this plant is mainly used as a medicinal raw material, but the above-ground parts are also a valuable source of health-promoting biologically active compounds.

A nurse-led intervention for carers of people with high-grade glioma: A case series of carers reporting high distress.

Background: Carers play an important role in supporting patients diagnosed with high-grade glioma (HGG). However, this experience is frequently distressing and many carers require support.

Objectives: To describe unmet needs of highly distressed carers of people with HGG and recommendations and referrals made by a nurse to support them within the Care-IS trial.

Self-Efficacy and Perceived Stress in Women Experiencing Preterm Birth.

Being an unexpected, undesired and life-threatening situation, preterm birth (PTB) is a stress-, anxiety- and depression-generating factor for women delivering prematurely. The aim of this study was to assess the relationship between self-efficacy, coping strategies and perceived stress in mothers who experienced preterm birth and full-term birth, to determine the needs for personalized emotional support. The study was conducted among 251 women divided into the preterm birth group (PBG) and the full-term birth group (FBG).

Analysis of Single Nucleotide Polymorphisms (SNPs) rs2234693 and rs9340799 of the Gene and the Risk of Breast Cancer.

Background/aim: The aim of this study was to analyze rs2234693 and rs9340799 polymorphisms of the ESR1 gene in the context of breast cancer risk in Polish patients.

Materials And Methods: The study involved a group of 117 patients with breast cancer and 106 controls. The analyses were carried out using the polymerase chain reaction - restriction fragments length polymorphism technique.

War and peace in public health education and training: a scoping review.

Background: Armed conflict and war are public health disasters. Public health action has a crucial role in conflict-related emergencies and rehabilitation but also in war prevention and peace promotion. Translating this into public health training and competencies has just started to emerge, especially in Europe.

The International Association for the Study of Lung Cancer Mesothelioma Staging Project: Proposals for the M Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Pleural Mesothelioma.

Introduction: The International Association for the Study of Lung Cancer developed a global multicenter database to propose evidence-based revisions for the ninth edition of the TNM classification of pleural mesothelioma (PM). This study analyzes the M category to validate eighth edition M category recommendations.

Methods: Cases were submitted electronically or by transfer of existing institutional databases for patients with histologically or cytologically confirmed PM.

Current approach to the management of preoperative iron deficiency anemia in colorectal cancer patients: a review of literature.

<b>Introduction:</b> The prevalence of preoperative anemia is the highest in the group of colorectal cancer (CRC) patients and may reach over 75%. The prevalence of anemia in CRC patients increases even further following surgery. Approximately 75-80% of anemic CRC patients present with absolute or functional iron deficiency (ID).