Publications by authors named "Anna Nobbe"

Background: As the largest US provider of cirrhosis care, the Veterans Health Administration (VA) is the ideal setting to assess patient-, clinician-, and site-level barriers to transplant evaluation.

Aims: To assess barriers to transplant evaluation referral among Veterans with cirrhosis or hepatocellular carcinoma (HCC).

Methods: Logistic regression assessed facility, patient, clinical, and distance factors associated with transplant referral for Veterans with cirrhosis or HCC, over 1 year.

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Background: The Veterans Health Administration provides care to more than 100,000 Veterans with cirrhosis.

Aims: This implementation evaluation aimed to understand organizational resources and barriers associated with cirrhosis care.

Methods: Clinicians across 145 Department of Veterans Affairs (VA) medical centers (VAMCs) were surveyed in 2022 about implementing guideline-concordant cirrhosis care.

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Introduction: Implementation strategies supporting the translation of evidence into practice need to be tailored and adapted for maximum effectiveness, yet the field of adapting implementation strategies remains nascent. We aimed to adapt "Getting To Outcomes" (GTO), a 10-step implementation playbook designed to help community-based organizations plan and evaluate behavioral health programs, into "Getting To Implementation" (GTI) to support the selection, tailoring, and use of implementation strategies in health care settings.

Methods: Our embedded evaluation team partnered with operations, external facilitators, and site implementers to employ participatory methods to co-design and adapt GTO for Veterans Health Administration (VA) outpatient cirrhosis care improvement.

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Article Synopsis
  • Spontaneous bacterial peritonitis (SBP) is a significant health issue leading to high mortality rates, and primary prophylaxis (SBPPr) using antibiotics like fluoroquinolones and TMP-SMX is commonly employed, though resistance to these drugs is a concern.
  • A study analyzed 7553 patients from the Veterans Health Administration to assess antibiotic resistance patterns of bacteria like E. coli and Klebsiella pneumoniae in first-time SBP episodes, especially focusing on the impact of SBPPr.
  • Results indicated that patients on SBPPr had higher resistance rates to ciprofloxacin and TMP-SMX, longer hospital stays, and greater chances of needing a liver transplant compared to those not on prophylaxis.
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Ascites is the most common and often the first decompensating event that occurs in cirrhosis. It has both a high symptom burden and high mortality rate. Increased abdominal girth, generalized abdominal pain, early satiety, and shortness of breath have a negative impact on quality of life.

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After implementing a successful hepatitis C elimination program, the Veterans Health Administration's (VHA) Hepatic Innovation Team (HIT) Collaborative pivoted to focus on improving cirrhosis care. This national program developed teams of providers across the country and engaged them in using systems redesign methods and population health approaches to improve care. The HIT Collaborative developed an Advanced Liver Disease (ALD) Dashboard to identify Veterans with cirrhosis who were due for surveillance for hepatocellular carcinoma (HCC) and other liver care, promoted the use of an HCC Clinical Reminder in the electronic health record, and provided training and networking opportunities.

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