Synthesis, Structure and Cytotoxicity Testing of Novel 7-(4,5-dihydro-1-imidazol-2-yl)-2-aryl-6,7-dihydro-2-imidazo[2,1-][1,2,4]triazol-3(5)-Imine Derivatives.

The appropriate 1-arylhydrazinecarbonitriles are subjected to the reaction with 2-chloro-4,5-dihydro-1-imidazole (), yielding 7-(4,5-dihydro-1-imidazol-2-yl)-2-aryl-6,7-dihydro-2-imidazo[2,1-][,,4]triazol-3(5)-imines , which are subsequently converted into the corresponding amides -, -, sulfonamides -, , ureas -, and thioureas -. The structures of the newly prepared derivatives -, -, -, -, -, -, and are confirmed by IR, NMR spectroscopic data, as well as single-crystal X-ray analyses of and . The in vitro cytotoxic potency of these compounds is determined on a panel of human cancer cell lines, and the relationships between structure and antitumor activity are discussed.