Oxidative stress increases in retinas of dogs in acute glaucoma but not in chronic glaucoma.

Objective: To test the hypothesis that oxidative stress occurs early in the pathogenesis of glaucoma in dogs.

Animals: Sections from eight control retinas and 25 retinas from dogs with primary glaucoma.

Methods: For retinas embedded in paraffin, sections were immunohistochemically stained for malondialdehyde (MDA) and 3-nitrotyrosine (NT).