Publications by authors named "Anna Mozhenkova"
Sickle cell disease (SCD)-associated chronic hemolysis promotes oxidative stress, inflammation, and thrombosis leading to organ damage, including liver damage. Hemoglobin scavenger receptor CD163 plays a protective role in SCD by scavenging both hemoglobin-haptoglobin complexes and cell-free hemoglobin. A limited number of studies in the past have shown a positive correlation of CD163 expression with poor disease outcomes in patients with SCD.
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- This study compares immune system recovery in HIV-positive and HIV-negative patients after undergoing autologous hematopoietic cell transplant (AHCT) for lymphoma, evaluating their immune responses at multiple time points.
- Principal component analysis revealed that both groups showed distinct immune cell compositions compared to healthy controls, but their profiles improved over time, indicating a trend towards normalcy.
- Key findings include that HIV-positive recipients had higher levels of certain activated T cells but lower counts of B cells and natural killer (NK) cells, suggesting specific immune challenges that could inform treatment strategies for these patients.
Epstein-Bar virus (EBV) can directly cause lymphoproliferative disease (LPD), including AIDS-defining lymphomas such as Burkitt's lymphoma and other non-Hodgkin lymphomas (NHL), as well as human immunodeficiency virus (HIV)-related Hodgkin lymphoma (HL). The prevalence of EBV in HL and NHL is elevated in HIV-positive individuals compared with the general population. Rates of incidence of AIDS-defining cancers have been declining in HIV-infected individuals since initiation of combination anti-retroviral therapy (cART) use in 1996.
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