Publications by authors named "Anna Monakova"
Adult stem cells maintaining tissue homeostasis and regeneration are tightly regulated by their specific microenvironments or stem cell niches. The dysfunction of niche components may alter the activity of stem cells and ultimately lead to intractable chronic or acute disorders. To overcome this dysfunction, niche-targeting regenerative medicine treatments such as gene, cell, and tissue therapy are actively investigated.
View Article and Find Full Text PDFIdiopathic male infertility is a highly prevalent diagnosis in developed countries with no specific treatment options. Although empirical medical treatment is widely used to restore male fertility, its efficacy remains limited and inconclusively proven. Therefore, the development of novel therapeutic approaches in this field is a high-priority task.
View Article and Find Full Text PDFArticle Synopsis
- Stem and progenitor cells in their niches are crucial for tissue and organ renewal in adults, and dysfunction in these niches can lead to serious health problems, including infertility.
- Male infertility, often without clear causes or treatments, may result from issues in the spermatogonial stem cell niche.
- Research suggests using mesenchymal stromal cells (MSCs) and their secretions to regenerate damaged niches, but further studies and specific animal models are needed to fully understand how they work in this context.