Vision-related quality of life in patients with occipital stroke.

Objectives: The aim of this study was to detect visual field defects (VFDs) after occipital infarction, investigate the rate of recovery and the impact of VFD upon vision-related quality of life (QoL).

Materials And Methods: Multicenter, prospective study including patients with MRI verified acute occipital infarction (NOR-OCCIP project). Ophthalmological examination including perimetry was performed within 2 weeks and after 6 months.

Visual dysfunction in multiple sclerosis.

Multiple sclerosis can give rise to signs and symptoms from the entire nervous system, including visual impairments. Visual impairments often go unreported because they are not obvious to patients, which means that doctors must ask about them specifically. Regular monitoring of vision is important, however, to provide personalised rehabilitation and assistive technologies, and thereby improve patients’ functioning and quality of life.

Maternal myasthenia gravis: a cause for arthrogryposis multiplex congenita.

Background: Arthrogryposis multiplex congenita (AMC) is a condition defined as contractures in more than two joints and in multiple body areas. The principal mechanism leading to the development of AMC in utero is decreased fetal movement.

Objective: Both fetal and maternal factors can lead to this condition, including maternal myasthenia gravis (MG) which is the topic of this review.

NMR spectroscopy of human eye tissues: a new insight into ocular biochemistry.

Background: The human eye is a complex organ whose anatomy and functions has been described very well to date. Unfortunately, the knowledge of the biochemistry and metabolic properties of eye tissues varies. Our objective was to reveal the biochemical differences between main tissue components of human eyes.

Metabolic profile of keratoconic cornea.

Purpose: To investigate the difference in metabolic profile of keratoconic and normal corneas using two different analysis methods.

Methods: Keratoconic corneas were obtained from patients (aged 19-27) during transplantation surgery. Control samples were obtained from human donors (aged 61-75) 1-8 h post-mortem.

Influence of donor age, post-mortem time and cold storage on metabolic profile of human cornea.

Purpose: Limited knowledge exists about the influence of donor age and death-to-preservation interval (DPI) on the metabolic properties of the cornea. The aim of this study is to investigate the relationship between both factors and metabolite content of the cornea.

Methods: Corneas from 15 human donors (age: 41-78 years) were obtained within 16 hrs post-mortem and kept in cold storage for 8 days.

Impact of organ culturing on metabolic profile of human corneas: preliminary results.

Purpose: It is suggested that the quality of corneal graft may depend on modifications that appear in the tissue during culturing. The aim of this study was to investigate the differences in the metabolic profile between cultured and noncultured human corneas.

Methods: Corneas from 12 donors were obtained post-mortem and cultured for 6-20 days.

Retinal nerve fibre layer attenuation: clinical indicator for vigabatrin toxicity.

Purpose: To investigate whether persistent visual field defects among patients exposed once to the antiepileptic drug vigabatrin (VGB) were associated with peripapillary retinal nerve fibre layer thickness (RNFLT) attenuation.

Methods: Nine individuals with partial epilepsy and VGB-attributed visual field loss (group 1; 18 eyes) and seven age- and gender-matched individuals with epilepsy and no previous VGB exposure (group 2; 14 eyes) were included in the study. Full-field 120 point screening perimetry out to 60 degrees from central fixation using the Humphrey Field Analyzer was performed.

Metabonomics--a new approach in ophthalmology.

Metabonomics is a new technology providing broad information about dynamic metabolic responses in living systems to pathophysiological stimuli or genetic modification. Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful methods in metabonomics; it is utilized to establish the metabolic profiles of biofluids, and is practically the only method capable of examining intact tissue samples. Experience with the application of metabonomics in eye research is still limited, yet this method provides the possibility of exploring metabolic processes in the eye in vivo.

Acute visual loss after spinal surgery.

Purpose: To report visual loss after prone spinal surgery.

Methods: Computed tomography scan, fundus photography, optical coherence tomography (OCT).

Results: A 56-year-old man demonstrated loss of vision in the left eye after cervical spinal surgery.

The effect of single and repeated UVB radiation on rabbit lens.

Background: In our previous investigations, a significant cumulative effect of ultraviolet radiation (UVR) on the corneal and aqueous humour metabolic profiles was revealed. The purpose of the present study was to monitor the alterations in the rabbit lenses under the same experimental design and thereby supplement and complete prior findings.

Methods: Albino rabbit eyes were exposed to single (312 nm, 3.

Changes in aqueous humour following single or repeated UVB irradiation of rabbit cornea.

Background: Aqueous humour is the main nutritive source for corneal and lenticular tissues, and knowledge of a possible cumulative effect of ultraviolet radiation (UVR) on its metabolic profile might be of great help in the assessment of cataract risks. By using high-resolution (1)H nuclear magnetic resonance (NMR) spectroscopy, it was possible to evaluate the effect of a single and repeated UVB radiation of the rabbit eye with the same overall dose on the aqueous humour.

Methods: Samples of aqueous humour from twenty-four albino white rabbit eyes were examined for the effects of UVB exposure (312 nm).

Postnatal biochemical changes in rat lens: an important factor in cataract models.

Purpose: Administration of several cataractogenic agents is effective during the first 21 days of rat lens development, a period of the highest sensitivity of the tissue. Thus, cataract formation and lens maturation affect the biochemical profile of rat lens simultaneously and might be difficult to evaluate separately. The purpose of this study was to use high-resolution magic angle spinning proton nuclear magnetic resonance (HR-MAS 1H NMR) to investigate exclusively the effect of maturation on the metabolic profile of rat lens.

Biological response in various compartments of the rat lens after in vivo exposure to UVR-B analyzed by HR-MAS 1H NMR spectroscopy.

Purpose: The purpose of the present study was to investigate metabolic changes in different compartments of the rat lens (anterior, nuclear, posterior, and equatorial) after exposure to an acute double threshold dose of ultraviolet-B radiation (UVR-B) by using high-resolution magic angle spinning (HR-MAS) (1)H nuclear magnetic resonance (NMR) spectroscopy and pattern recognition (PR) METHODS: methods. One eye in each of 28 6-week-old female albino Sprague-Dawley rats was exposed to in vivo 7.5 kJ/m2 UVR-B for 15 minutes.

Biochemical changes in selenite cataract model measured by high-resolution MAS H NMR spectroscopy.

Purpose: To correlate certain levels of lens opacification with high-resolution magic-angle spinning proton nuclear magnetic resonance (HR-MAS (1)H NMR) spectroscopy analysis of the biochemical changes in rat lenses in a selenite cataract model.

Methods: Selenite cataract was induced by injecting 13-day-old Sprague-Dawley rat pups with a single subcutaneous dose of sodium selenite (3.28 mg/kg in 0.

Epidemiology and heritability of astigmatism in Norwegian twins: an analysis of self-reported data.

Purpose: To describe the occurrence and heritability of astigmatism in a population-based sample of Norwegian twins.

Methods: Self-reported history of astigmatism based on questionnaire responses was used to estimate the prevalence and incidence rates of astigmatism from birth through 31 years in 8,045 twins. Kaplan-Meier analysis and log-binomial regression were used to study the conditional and relative risk of astigmatism in twin pairs by sex and zygosity.

The effect of single and repeated UVB radiation on rabbit cornea.

Background: Cumulative effect of ultraviolet radiation (UVR) is an important aspect of UV corneal damage. The purpose of this study was to apply high resolution magic angle spinning proton nuclear magnetic resonance (HR-MAS 1H NMR) spectroscopy to evaluate the effect of single and repeated UV radiation exposure of the same overall dose on the rabbit cornea.

Methods: Corneal surfaces of 24 normal rabbit eyes were examined for the effects of UVB exposure (312 nm).