Publications by authors named "Anna McCracken"
Background: The receptor tyrosine kinase (RTK)/Ras/Raf/MEK/ERK signaling pathway is one of the most tumorigenic pathways in cancer, with its hyperactivation strongly linked to the aggressive nature of glioblastoma (GBM). Although extensive research has focused on developing therapeutics targeting this pathway, clinical success remains elusive due to the emergence of resistance mechanisms.
Objective: This review investigates how inhibition of the RTK/Ras/Raf/MEK/ERK pathway alters transcription factors, contributing to acquired resistance mechanisms in GBM.
Article Synopsis
- Same day discharge after minimally invasive gynecology oncology surgery is both safe and sustainable, with rates maintaining around 72% one year post-implementation of a quality improvement program.
- The program led to a significant decrease in unnecessary post-operative clinic visits and bowel prep usage, while not increasing complication rates or hospital readmissions.
- Factors identified as significant in influencing same day discharge included the start time of the procedure and the level of narcotic use during hospitalization.