Activation and functional connectivity of cerebellum during reading and during arithmetic in children with combined reading and math disabilities.

Background: Reading and math constitute important academic skills, and as such, reading disability (RD or developmental dyslexia) and math disability (MD or developmental dyscalculia) can have negative consequences for children's educational progress. Although RD and MD are different learning disabilities, they frequently co-occur. Separate theories have implicated the cerebellum and its cortical connections in RD and in MD, suggesting that children with combined reading and math disability (RD + MD) may have altered cerebellar function and disrupted functional connectivity between the cerebellum and cortex during reading and during arithmetic processing.

Neurocognitive mechanisms of co-occurring math difficulties in dyslexia: Differences in executive function and visuospatial processing.

Children with dyslexia frequently also struggle with math. However, studies of reading disability (RD) rarely assess math skill, and the neurocognitive mechanisms underlying co-occurring reading and math disability (RD+MD) are not clear. The current study aimed to identify behavioral and neurocognitive factors associated with co-occurring MD among 86 children with RD.

The role of the angular gyrus in arithmetic processing: a literature review.

Since the pioneering work of the early 20th century neuropsychologists, the angular gyrus (AG), particularly in the left hemisphere, has been associated with numerical and mathematical processing. The association between the AG and numerical and mathematical processing has been substantiated by neuroimaging research. In the present review article, we will examine what is currently known about the role of the AG in numerical and mathematical processing with a particular focus on arithmetic.

The relationship between phonological processing and arithmetic in children with learning disabilities.

Phonological processing skills have not only been shown to be important for reading skills, but also for arithmetic skills. Specifically, previous research in typically developing children has suggested that phonological processing skills may be more closely related to arithmetic problems that are solved through fact retrieval (e.g.

Dorsal visual stream activity during coherent motion processing is not related to math ability or dyscalculia.

Math disability (MD) or developmental dyscalculia is a highly prevalent learning disability involving deficits in computation and arithmetic fact retrieval and is associated with dysfunction of parietal and prefrontal cortices. It has been suggested that dyscalculia (and other learning disabilities and developmental disorders) can be viewed in terms of a broader 'dorsal stream vulnerability,' which could explain a range of dorsal visual stream function deficits, including poor coherent visual motion perception. Behavioral evidence from two studies in typical children has linked performance on visual motion perception to math ability, and a third behavioral study reported poorer visual motion perception in a small group of children with MD compared to controls.

Shared Neural Circuits for Visuospatial Working Memory and Arithmetic in Children and Adults.

Visuospatial working memory (VSWM) plays an important role in arithmetic problem solving, and the relationship between these two skills is thought to change over development. Even though neuroimaging studies have demonstrated that VSWM and arithmetic both recruit frontoparietal networks, inferences about common neural substrates have largely been made by comparisons across studies. Little work has examined how brain activation for VSWM and arithmetic converge within the same participants and whether there are age-related changes in the overlap of these neural networks.

Functional neuroanatomy of arithmetic in monolingual and bilingual adults and children.

Prior studies on the brain bases of arithmetic have not focused on (or even described) their participants' language backgrounds. Yet, unlike monolinguals, early bilinguals have the capacity to solve arithmetic problems in both of their two languages. This raises the question whether this ability, or any other experience that comes with being bilingual, affects brain activity for arithmetic in bilinguals relative to monolinguals.

The neural association between arithmetic and basic numerical processing depends on arithmetic problem size and not chronological age.

The intraparietal sulcus (IPS) is thought to be an important region for basic number processing (e.g. symbol-quantity associations) and arithmetic (e.

Developmental specialization of the left intraparietal sulcus for symbolic ordinal processing.

Symbolic numbers have both cardinal (symbol-quantity) and ordinal (symbol-symbol) referents. Despite behavioural evidence suggesting distinct processing of cardinal and ordinal referents, little consensus has emerged from the neuroimaging literature on whether these processes have shared or distinct neural underpinnings. Moreover, it remains unclear how the neural correlates of cardinal and ordinal processing change with age.

How do individual differences in children's domain specific and domain general abilities relate to brain activity within the intraparietal sulcus during arithmetic? An fMRI study.

Previous research has demonstrated that children recruit the intraparietal sulcus (IPS) during arithmetic, which has largely been attributed to domain-specific processes such as quantity manipulations. However, the IPS has also been found to be important for domain-general abilities, such as visuo-spatial working memory (VSWM). Based on the current literature it is unclear whether individual differences in domain-specific skills, domain-general skills, or a combination of the two, are related to the recruitment of the IPS during arithmetic.

Strong causal claims require strong evidence: A commentary on Wang and colleagues.

In this commentary, we provide a discussion of the findings by Wang, Odic, Halberda, and Feigenson recently published in the Journal of Experimental Child Psychology (2016, Vol. 147, pp. 82-99).

Trajectories of Symbolic and Nonsymbolic Magnitude Processing in the First Year of Formal Schooling.

Sensitivity to numerical magnitudes is thought to provide a foundation for higher-level mathematical skills such as calculation. It is still unclear how symbolic (e.g.

Drawing connections between white matter and numerical and mathematical cognition: a literature review.

In this review we examine white matter tracts that may support numerical and mathematical abilities and whether abnormalities in these pathways are associated with deficits in numerical and mathematical abilities. Diffusion tensor imaging (DTI) yields indices of white matter integrity and can provide information about the axonal organization of the brain. A growing body of research is using DTI to investigate how individual differences in brain microstructures relate to different numerical and mathematical abilities.

Individual differences in left parietal white matter predict math scores on the Preliminary Scholastic Aptitude Test.

Mathematical skills are of critical importance, both academically and in everyday life. Neuroimaging research has primarily focused on the relationship between mathematical skills and functional brain activity. Comparatively few studies have examined which white matter regions support mathematical abilities.

microParaflo biochip for nucleic acid and protein analysis.

We describe in this chapter the use of oligonucleotide or peptide microarrays (arrays) based on microfluidic chips. Specifically, three major applications are presented: (1) microRNA/small RNA detection using a microRNA detection chip, (2) protein binding and function analysis using epitope, kinase substrate, or phosphopeptide chips, and (3) protein-binding analysis using oligonucleotide chips. These diverse categories of customizable arrays are based on the same biochip platform featuring a significant amount of flexibility in the sequence design to suit a wide range of research needs.

Microfluidic PicoArray synthesis of oligodeoxynucleotides and simultaneous assembling of multiple DNA sequences.

Large DNA constructs of arbitrary sequences can currently be assembled with relative ease by joining short synthetic oligodeoxynucleotides (oligonucleotides). The ability to mass produce these synthetic genes readily will have a significant impact on research in biology and medicine. Presently, high-throughput gene synthesis is unlikely, due to the limits of oligonucleotide synthesis.