Publications by authors named "Anna Maria Seekatz"
The role of the gut microbiome in colonization resistance and recurrent infection.
Therap Adv Gastroenterol
November 2022
Article Synopsis
- The human gut microbiome is crucial for overall health and helps prevent infections, but disruptions can lead to diseases, especially after antibiotic use.
- Standard antibiotics may not resolve microbiome imbalances and can actually worsen the situation, which is particularly problematic for patients with recurrent Clostridioides difficile infections (CDI).
- Fecal microbiota transplantation (FMT) shows promise in restoring gut health but faces challenges such as safety concerns and the need for more regulated biotherapeutic options.
High-resolution profiling of the gut microbiome reveals the extent of burden.
NPJ Biofilms Microbiomes
December 2017
Article Synopsis
- * A high-resolution sequencing method revealed that C. difficile was found in 131 out of 156 CDI cases (1.78% abundance) and in 18 out of 211 healthy controls (0.008% abundance), suggesting significant differences in gut microbiomes between these groups.
- * The study also noted that high levels of C. difficile persisted in some infants over several months, and that its presence was negatively associated with various other bacterial species in the gut, indicating potential implications
Background: Recurrent Clostridium difficile infection (CDI) remains problematic, with up to 30 % of individuals diagnosed with primary CDI experiencing at least one episode of recurrence. The success of microbial-based therapeutics, such as fecal microbiota transplantation, for the treatment of recurrent CDI underscores the importance of restoring the microbiota. However, few studies have looked at the microbial factors that contribute to the development of recurrent disease.
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