Publications by authors named "Anna Maria Giulia Farci"
Background: Cancer patients submitted to gastrointestinal surgery are at risk of thiamine deficiency (TD) and Wernicke's encephalopathy (WE). Although permanent neurological damage and death could be prevented by a timely replacement therapy, they often remain undiagnosed and untreated. We hypothesized that WE remains unrecognized because most cases may manifest several months after hospital discharge.
View Article and Find Full Text PDFObjective: To evaluate the efficacy and safety of disulfiram for treatment of binge eating disorder.
Method: Two hundred and fifty milligrams per day of disulfiram was administered to 12 patients affected by binge eating disorder for 16 weeks; the number of binge eating episodes per week and the number of participants who reported side effects were evaluated.
Results: Nine participants (75.
Herein we report the results of mutation analysis of the ATP7B gene in a group of 134 Wilson disease (WD) families (268 chromosomes) prevalently of Italian origin. Using the SSCP and sequencing methods we identified 71 disease-causing mutations. Twenty-four were novel, while 19 more mutations already described, were identified in new populations in this study.
View Article and Find Full Text PDFArticle Synopsis
- Recent research shows that the Wilson disease (WD) protein specifically interacts with the MURR1 protein, prompting an investigation into the role of MURR1 in WD and similar copper metabolism disorders.
- The study involved genetic analysis of the MURR1 gene in various patient groups, revealing six rare nucleotide substitutions but no significant differences compared to control groups.
- Findings indicate that the MURR1 gene likely does not play a primary role in Wilson disease's development, suggesting the need for further studies with larger patient samples to explore potential roles of these genetic variations.