Publications by authors named "Anna Maria Di Cosola"
Article Synopsis
- The study focuses on how the carrier ligand -1,3-diaminocyclohexane (-1,3-DACH) affects the formation and stability of platinum drugs targeting guanine residues in DNA.
- The research highlights the asymmetric nature of the -1,3-DACH ligand, which influences the stereochemistry and conformations of platinum-DNA adducts, preferring distinct conformations for each adduct type.
- Additionally, the study identifies two isomeric forms of the (-1,3-DACH)Pt(d(GpG)) adduct, noting a predominance of the HH conformer with some presence of the ΔHT conformer, suggesting complexity in how these oligomeric structures interact with DNA.
