Publications by authors named "Anna Maria Asunis"
Light chain cast nephropathy (LCCN) in multiple myeloma often leads to severe and poorly reversible acute kidney injury. Severe renal impairment influences the allocation of chemotherapy and its tolerability; it also affects patient survival. Whether renal biopsy findings add to the clinical assessment in predicting renal and patient outcomes in LCCN is uncertain.
View Article and Find Full Text PDFArticle Synopsis
- The VALIGA study analyzed the use of the Oxford Classification for immunoglobulin A nephropathy (IgAN) in 1147 patients across 13 European countries, focusing on biopsy scoring and its impact on treatment decisions.
- The findings revealed that local pathologists tended to report more lesions than central pathologists, and variability in scoring was noted, particularly for mesangial hypercellularity and endocapillary hypercellularity.
- Ultimately, the study highlighted discrepancies in pathology assessments affecting treatment choices and clinical outcomes, suggesting that central reviews could offer more reliable evaluations for certain lesions.
Background: To provide further information on the clinical and pathological prognostic factors in triple-negative breast cancer (TNBC), for which limited and inconsistent data are available.
Methods: Pathological characteristics and clinical records of 841 TNBCs diagnosed between 1994 and 2015 in four major oncologic centers from Sardinia, Italy, were reviewed. Multivariate hazard ratios (HRs) for mortality and recurrence according to various clinicopathological factors were estimated using Cox proportional hazards models.
Purpose: The purpose of this study was to investigate potential associations between invasive breast cancer sonographic (US) findings and histopathologic patterns and biomarkers.
Methods: One hundred consecutive women with invasive breast cancer treated in the Breast Diagnostic Center of Brotzu Hospital in Cagliari, Italy, from January to October 2013, were retrospectively evaluated. Two experienced breast radiologists independently evaluated hard copies of US examinations performed during the US-guided biopsy procedure.
The Oxford Classification of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as independent predictors of outcome. Whether it applies to individuals excluded from the original study and how therapy influences the predictive value of pathology remain uncertain. The VALIGA study examined 1147 patients from 13 European countries that encompassed the whole spectrum of IgAN.
View Article and Find Full Text PDF