Publications by authors named "Anna Mandra"

Post-exposure prophylaxis (PEP) for rabies is widely administered and highly effective. Nevertheless, sporadic breakthrough infections (ie, rabies in people who have started PEP) have been reported. We conducted a systematic review of articles published between Jan 1, 1980 and June 1, 2022 to characterise breakthrough infections.

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Objective: In March 2018, the US Department of Defense (DOD) added the smallpox vaccination, using ACAM2000, to its routine immunizations, increasing the number of persons receiving the vaccine. The following month, Fort Hood reported a cluster of 5 myopericarditis cases. The Centers for Disease Control and Prevention and the DOD launched an investigation.

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Although canine rabies virus variant (CRVV) was successfully eliminated from the United States after approximately 6 decades of vaccination campaigns, licensing requirements, and stray animal control, dogs remain the principal source of human rabies infections worldwide. A rabies vaccination certificate is required for dogs entering the United States from approximately 100 countries with endemic CRVV, including Egypt (1). On February 25, 2019, rabies was diagnosed in a dog imported from Egypt, representing the third canine rabies case imported from Egypt in 4 years (2,3).

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Article Synopsis
  • - The largest monkeypox outbreak in West Africa began in Nigeria in September 2017, leading to the first human cases being reported outside Africa when four travelers brought the virus to the UK, Israel, and Singapore.
  • - An analysis of epidemiological and molecular data revealed that the strains found in the travelers and a Nigerian case shared a recent common ancestor, indicating a possible single source of infection within certain Nigerian states.
  • - Findings suggest that the low genetic variation among the exported cases hints at a small, related group of monkeypox isolates as the source, potentially linked to genetic diversity in the monkeypox strains circulating in Bayelsa, Delta, and Rivers states.
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