Publications by authors named "Anna M Zhang"
Article Synopsis
- Patients with predominantly antibody deficiency (PAD) initially produce lower anti-SARS-CoV-2 spike antibodies after their first two vaccine doses compared to healthy individuals; however, their responses to subsequent vaccinations require further research.
- A study analyzed anti-spike antibody levels in 117 adults with PAD and 192 healthy controls after up to 5 vaccine doses, looking specifically at antibody responses and neutralization effectiveness against different SARS-CoV-2 variants.
- While individuals with severe PAD showed greater increases in antibody levels with more vaccinations, overall, all PAD patients experienced improved anti-spike antibodies, which correlated with their ability to neutralize the virus strains.
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) is a prevalent and increasing global cancer with a high chance of relapse post-treatment, especially in patients with advanced disease.
- The study highlights the overexpression and activation of the cAMP Regulated Transcription Coactivator 2 (CRTC2) in HNSCC, which is linked to a poor patient prognosis, particularly in HPV-positive cases.
- Findings suggest that targeting CRTC2 and its signaling pathways could reduce tumor growth and spread, indicating potential new therapeutic strategies for treating HPV(+) HNSCC.
There continues to be a significant shortage of donor livers for transplantation. One impediment is the discard rate of fatty, or steatotic, livers because of their poor post-transplant function. Steatotic livers are prone to significant ischemia-reperfusion injury (IRI) and data regarding how best to improve the quality of steatotic livers is lacking.
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