Publications by authors named "Anna M Swanson"
Article Synopsis
- A study on pregnant guinea pigs aimed to improve fetal growth by overexpressing VEGF (Vascular Endothelial Growth Factor) in the uterine arteries, drawing parallels to human placental function.
- Ad.VEGF-A treatment resulted in increased fetal weight and larger organ sizes compared to a control group treated with Ad.LacZ, indicating a positive effect on growth.
- The results showed that the treatment enhanced blood flow in the uterine artery and boosted VEGF levels in the target tissues, suggesting a potentially effective strategy for addressing fetal growth restriction.
The abnormal decrease or the lack of oxygen supply to cells and tissues is called hypoxia. This condition is commonly seen in various diseases such as rheumatoid arthritis and atherosclerosis, also in solid cancers. Pre-clinical and clinical studies have shown that hypoxic cancers are extremely aggressive, resistant to standard therapies (chemotherapy and radiotherapy), and thus very difficult to eradicate.
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