Publications by authors named "Anna M Potenski"
Article Synopsis
- Caspases play a role in various cellular functions beyond just cell death, such as differentiation, axonal pathfinding, and proliferation, but many existing tools for studying them lack specificity.
- This report highlights a novel approach to target and study caspase-9 in the nervous system using a new inhibitor and genetic methods, validated through immunohistochemical techniques.
- The study focuses on retinal neuronal tissue to explore both apoptotic and non-apoptotic functions of caspase-9, aiming to enhance our understanding of cell biology and identify potential therapeutic targets for diseases.
Advancements in ophthalmic imaging tools offer an unprecedented level of access to researchers working with animal models of neurovascular injury. To properly leverage this greater translatability, there is a need to devise reproducible methods of drawing quantitative data from these images. Optical coherence tomography (OCT) imaging can resolve retinal histology at micrometer resolution and reveal functional differences in vascular blood flow.
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Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after hypoxia-ischemia is a critical event in subsequent dysfunction of the blood-retina barrier, using a panel of interrelated ophthalmic in vivo imaging measures in a mouse model of retinal vein occlusion (RVO). Rapid nonapoptotic activation of caspase-9 and its downstream effector caspase-7 in endothelial cells promotes capillary ischemia and retinal neurodegeneration.
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