Publications by authors named "Anna M Ochocka-Fox"
Article Synopsis
- Lymph nodes (LNs) are important in detecting colorectal cancer spread, but traditional imaging methods like CT and MRI have limitations in accurately assessing them.
- B-mode and contrast-enhanced ultrasound (CEUS) could enhance LN detection, but further research is needed before they can be widely adopted in clinical settings.
- A pilot study using a mouse model found that a new scoring system based on various LN characteristics may provide better predictive accuracy for cancer involvement than simply measuring LN size.
Vitamin D deficiency is associated with risk of several common cancers, including colorectal cancer (CRC). Here we have utilized patient derived epithelial organoids (ex vivo) and CRC cell lines (in vitro) to show that calcitriol (1,25OHD) increased the expression of the CRC tumor suppressor gene, CDH1, at both the transcript and protein level. Whole genome expression analysis demonstrated significant differential expression of a further six genes after 1,25OHD treatment, including genes with established links to carcinogenesis GADD45, EFTUD1 and KIAA1199.
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