Publications by Anna M Chytil

Publications by authors named "Anna M Chytil"

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Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro.

Lu Xie Brian K Law Anna M Chytil Kimberly A Brown Mary E Aakre

Neoplasia

April 2005

Transforming growth factor-beta1 (TGF-beta1) can be tumor-suppressive through the activation of the Smad-mediated signaling pathway. TGF-beta1 can also enhance tumor progression by stimulating epithelial-to-mesenchymal transition (EMT) through additional pathways. EMT is characterized by the acquisition of a fibroblast-like cell morphology, dissolution of tight junctions, disruption of adherence junctions, and formation of actin stress fibers.

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