Publications by authors named "Anna Luisa Leo"
Article Synopsis
- Women are at a high risk of frailty, and factors like diabetes and hypertension increase this risk, with metformin potentially helping to reduce frailty symptoms in post-menopausal women.
- A study was conducted involving frail older women and men with diabetes and hypertension to evaluate the cognitive effects of an extended-release formulation of metformin over 6 months.
- Results showed significant improvements in cognitive performance for women taking extended-release metformin compared to those not treated, as well as differences between treatment responses in men and women, indicating the drug's positive impact on cognitive health in this demographic.
Background: Diabetes and hypertension are common in older adults and represent established risk factors for frailty. Frailty is a multidimensional condition due to reserve loss and susceptibility to stressors with a high risk of death, hospitalizations, functional and cognitive impairment. Comorbidities such as diabetes and hypertension play a key role in increasing the risk of mortality, hospitalization, and disability.
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