Publications by authors named "Anna Leonidovna Kaysheva"
Three-helix bundle and SH3-type barrels: autonomously stable structural motifs in small and large proteins.
Kirill Sergeevich Nikolsky Liudmila Ivanovna Kulikova Denis Vitalievich Petrovskiy Vladimir Removich Rudnev Tatiana Vladimirovna Butkova Anna Leonidovna Kaysheva
J Biomol Struct Dyn
October 2024
Article Synopsis
- The study explores two types of protein structures, three-helix bundles and SH3-type barrels, across various organisms using a neural graph network to analyze their spatial folds.
- Molecular experiments were conducted on small proteins with these structures, evaluating parameters like stability and structural integrity at different temperatures (300K, 340K, and 370K).
- The research aims to show that it is possible to analyze these protein folds independently from their protein environment, leading to improved efficiency and reduced computation time without losing essential information.
CD-based optico-acoustical biosensor (OAB) was used for detection of various types of proteins represented by bovine serum albumin (BSA), heme-containing myoglobin (Mb), monoclonal antibody against viral protein marker of hepatitis B (anti-HBsAg) and membrane-bound cytochrome P450scc (P450scc). We applied standard compact disc reader (CD-ROM) as an optical analyzer and a standard compact disc (CD) as a biochip containing immobilized protein molecules. This biosensor can translate into a digital code the changes of optical signal from the proteins and their complexes immobilized on the CD surface.
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