Motor adaptation in deaf and hearing native signers.

Previous studies have suggested that deafness could lead to deficits in motor skills and other body-related abilities. However, the literature regarding motor skills in deaf adults is scarce and existing studies often included participants with heterogeneous language backgrounds and deafness etiologies, thus making it difficult to delineate the effects of deafness. In this study, we investigated motor learning in deaf native signers and hearing nonsigners.

Sign learning of hearing children in inclusive day care centers-does iconicity matter?

An increasing number of experimental studies suggest that signs and gestures can scaffold vocabulary learning for children with and without special educational needs and/or disabilities (SEND). However, little research has been done on the extent to which iconicity plays a role in sign learning, particularly in inclusive day care centers. This current study investigated the role of iconicity in the sign learning of 145 hearing children (2;1 to 6;3 years) from inclusive day care centers with educators who started using sign-supported speech after a training module.

Developmental experiences alter the temporal processing characteristics of the visual cortex: Evidence from deaf and hearing native signers.

To date, the extent to which early experience shapes the functional characteristics of neural circuits is still a matter of debate. In the present study, we tested whether congenital deafness and/or the acquisition of a sign language alter the temporal processing characteristics of the visual system. Moreover, we investigated whether, assuming cross-modal plasticity in deaf individuals, the temporal processing characteristics of possibly reorganised auditory areas resemble those of the visual cortex.

The interaction of the visuo-spatial and the vestibular system depends on sensory experience in development.

In hearing individuals, vestibular and visuo-spatial functions seem to be functionally linked. Previous studies have suggested that congenitally deaf individuals are at a higher risk for vestibular problems, which in hearing adults have often been found to be associated with impairments in visuo-spatial processing. However, communicating in a sign language provides extensive practice in visuo-spatial processing, which might counteract negative effects of vestibular impairments.

Neural correlates of semantic and syntactic processing in German Sign Language.

The study of deaf and hearing native users of signed languages can offer unique insights into how biological constraints and environmental input interact to shape the neural bases of language processing. Here, we use functional magnetic resonance imaging (fMRI) to address two questions: (1) Do semantic and syntactic processing in a signed language rely on anatomically and functionally distinct neural substrates as it has been shown for spoken languages? and (2) Does hearing status affect the neural correlates of these two types of linguistic processing? Deaf and hearing native signers performed a sentence judgement task on German Sign Language (Deutsche Gebärdensprache: DGS) sentences which were correct or contained either syntactic or semantic violations. We hypothesized that processing of semantic and syntactic violations in DGS relies on distinct neural substrates as it has been shown for spoken languages.

Does listing for heart transplant for longer than 30 days before ventricular assist device implantation influence utilization of psychotherapeutic support and outcome?

Objectives: Previous studies indicate that patients with mechanical ventricular assist devices (VADs) experience high psychosocial and emotional distress. Listing for transplant may trigger psychosocial adjustment to the transplantation as an upcoming critical life-event. We hypothesized that patients could profit from this adaptation when implantation of a VAD becomes necessary.

Supportive psychotherapy for patients with heart transplantation or ventricular assist devices.

Objective: Both heart transplant (HTX) candidates and patients on ventricular assist device (VAD) support suffer from severe heart failure and have to fear life-threatening complications. For both patient groups, the importance of screening for and treatment of psychosocial problems and mental disorders to optimize compliance and survival has been acknowledged. We compared the use of psychotherapeutic support by patients with primary HTX, on VAD support, either on destination therapy or to be transplanted, and successfully bridged to transplant.

Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene.

A point mutation (G --> C) in the gene promoter for the human nitric oxide synthase (NOS) 2 at position -954 is associated with protection against severe Plasmodium falciparum malaria in Gabon. Carriers of this mutation show higher basal levels of nitric oxide production than wild type individuals. To obtain information about the possible binding transcription factors, nucleic proteins from the lung carcinoma cell line were enriched by affinity chromatography using DEAE-Sepharose and immobilized oligonucleotides derived from the promoter sequence.