The in vitro activity of selected mouthrinses on Candida strains isolated from the oral cavity.

The purpose of this in vitro study was to determine the effects of 13 mouth rinses on one hundred Candida strains isolated from the oral cavity of patients. Five of the rinses had no antifungal activity. Chlorhexidine, Colgate and Dentosept acted on all isolated strains; Corsodyl did not act on C.

The in vitro activity of selected mouthrinses on the reference strains of Trichomonas tenax and Entamoeba gingivalis.

Protozoa, such as Trichomonas tenax, Entamoeba gingivalis and Leishmania braziliensis, may be present in the mouth but their role in the pathophysiology of oral diseases is not clear yet. The use of various types of mouthrinses plays an important role in maintaining proper oral hygiene and in removing some of the microbial components from the oral cavity. The purpose of this study was to investigate the effects of selected mouthrinses on the reference strains of Trichomonas tenax and Entamoeba gingivalis which can be a part of the oral cavity microbiota.

Drug susceptibility of fungi isolated from ICU patients.

Candida species can be a reason of infections associated with high morbidity and mortality. The risk of invasive candidosis for patients admitted to intensive care units (ICUs) is increased due to immunosuppressive states, prolonged length of stay, broad-spectrum antibiotics and Candida colonization. The aim of the study was to determine selected properties of fungi isolated from patients treated in the ICUs of hospitals in Lodz.

Prevalence of fungi in cases of geographical and fissured tongue.

One of the most common malformations of the tongue is fissured tongue, very often, is accompanied by geographic tongue; the etiopathogenesis of them is not known. The aim of study was to evaluate the prevalence of fungi in cases of fissured and geographic tongue, and to determine their species and susceptibility to selected antifungal drugs. The study included 104 patients with fissured and/or geographical tongue.

Cigarette smoking induces overexpression of c-Met receptor in microvessels of oral lichen planus.

Introduction: Cigarette smoking is related to many pathological conditions; however, chemical substances affect the oral cavity first, so it is important to consider its influence on oral mucosa and oral potentially pre-malignant lesions. The aim of this study was to investigate the effect of smoking on microvessel density in oral lichen planus. Special emphasis was placed on examining the relationship between the expression of c-Met receptor in blood vessels and smoking habits.

Expression of Th1/Th2/Th3/Th17-related genes in recurrent aphthous ulcers.

The pathogenesis of recurrent aphthous ulceration (RAU) is unknown, although an abnormal immune reaction appears to be involved. RAU may result from oral epithelium damage caused by T cell-mediated immune response. To improve understanding of the role of T cells in RAU, the present study analyzed.

Knowledge on Lyme disease among foresters.

Objectives: The first aim was an attempt to evaluate the level of knowledge on Lyme disease among people whose profession involves working in the forest; the second--recognition of the health problems that should be included in health education programmes concerning Lyme disease in this group of professionals.

Materials And Methods: The study was performed on 159 subjects.

Results: Only 15% know the etiological factor of disease, 98%--the main cause of infection, and route of pathogen transmission.

[The immune response to fungal infections].

In mycoses congenital--nonspecific innate as well as acquired immunity (involving neutrophiles, monocytes, macrophages, dendritic cells and lymphocytes) both play important roles in host defence. Th1 lymphocytes release cytokines (IL-2, IL-12, IFN gamma) and stimulate cytotoxic cells and neutrophiles to destroy fungal cells. Th2 lymphocytes, on the other hand, suppress cellular immunity by releasing the cytokines IL-4, IL-6 and IL-10 which counter regulate the secretion of IL-2, IL-12, IFN gamma and depress the activity of macrophages.

[Occurence of fungi in oral cavity of patients with periodontitis].

The role of fungi in the etiology and pathogenesis of periodontal diseases is unclear. What more, there exist only few studies concerning occurrence of fungi in the oral cavity of patients with periodontitis. The aim of the study was to assess the frequency of fungi occurrence and to search relationship between its presence and the state of paradontium, indices of oral hygiene as well as to evaluate periodontal treatment needs.

Dysfunction of CD4+CD25high T regulatory cells in patients with recurrent aphthous stomatitis.

Background: Recurrent aphthous stomatitis (RAS) is a chronic inflammatory disease of unknown etiology characterized by recurring formation of painful oral ulcers. RAS may result from oral epithelium damage caused by T-cell-mediated immune response. CD4(+)CD25(+) T regulatory (Treg) cells suppress proliferation and effector functions of other immune cells, and therefore are crucial in regulating the immune response.

[Clinical evaluation of periodontium in pregnant women with risk of preterm birth].

Objectives: The aim of the study was to evaluate condition of the periodontium in pregnant women with pathological progress of the pregnancy, clinically and to compare it to periodontium in pregnant women in good health.

Design: Over the last years, the studies have described that periodontitis caused by dental plaque, could be the risk factor for preterm birth and low birth weight.

Materials And Methods: This study was performed in 80 pregnant women, 40 with pathologic pregnancy and 40 with normal pregnancy in it.

[Familial infections with Trichomonas tenax (O.F. Müller, 1773), Dobel, 1939].

Aim of the study was to research familial occurrence of Trichomonas tenax and relationship between infection with the protozoan and both a state of parodontium and hygiene of oral cavity. The study involved 10 families (22 individuals). Trichomonas tenax was found in 16 patients.

[Biological action and clinical application of shark liver oil].

Fish oils contain several active compounds that modify cell activity and influence various functions of the body. Shark liver oils are rich in alkylglycerols and squalene, but contain relatively low amounts of n-3 polyunsaturated fatty acids. Alkylglycerols may control immune response possibly throw modification of platelet activating factor (PAF) and diacylglycerol (DAG) production.

[Invasion of Trichomonas tenax in patients with periodontal diseases].

The aim of the study was to analyze the frequency of occurrence of Trichomonas tenax in patients with periodontitis and also to check the relationship between the occurrence of the protozoan and the indices of oral hygiene, and to evaluate periodontal treatment needs. The study involved 91 individuals aged 23-79 years (52 women and 39 men). 34 of them were infected with Trichomonas tenax.

Predominance of Type 1 cytokines and decreased number of CD4(+)CD25(+high) T regulatory cells in peripheral blood of patients with recurrent aphthous ulcerations.

Recurrent aphthous ulcerations (RAU) are a chronic inflammatory disease with evidence of inappropriate immune response. Previous studies have suggested cell-mediated activation of immune response towards common micro-organisms of oral cavity in RAU. In this investigation, we explored cytokine production by peripheral blood mononuclear cells (PBMC) and T regulatory cell population in blood of active and remission RAU patients as crucial factors for maintenance of peripheral tolerance.

Innate immune system is implicated in recurrent aphthous ulcer pathogenesis.

Background: Recurrent aphthous ulcers (RAU) is a chronic inflammatory disease with evidence of inappropriate immune response. This study presents the status of innate immune system in RAU.

Methods: Twenty RAU patients and 19 healthy individuals were selected.