Cumulus cell gene expression in luteal-phase-derived oocytes after double stimulation in one menstrual cycle.

Research Question: Does double stimulation (DuoStim) affect cumulus cell gene expression in luteal-phase-derived oocytes?

Design: This prospective observational study included 39 patients with reduced ovarian reserve. Fifteen patients (group 1) underwent IVF with a gonadotrophin-releasing hormone antagonist in the follicular phase and 24 patients (group 2) underwent DuoStim. A total of 149 cumulus cell samples were divided into two groups according to the phase of the cycle: group 1 included 55 follicular-phase-derived oocytes and group 2 included 94 luteal-phase-derived oocytes.