Publications by authors named "Anna Kolano"
Purpose: To compare plan quality among photon volumetric arc therapy (VMAT), Gamma Knife, and three different proton beam modalities.
Methods: Fifty-five brain lesions from 20 patients were planned with three different proton spot size ranges of cyclotron-generated proton beams, CPBs (spot size σ: 2.7-7.
Article Synopsis
- Pencil beam scanning (PBS) proton therapy is affected by interplay effects due to organ motion, primarily from respiration in the thoracic region, which can vary based on the type of proton accelerator used.
- The study evaluated how different PBS proton accelerators (cyclotron-generated and linear accelerator beams) and spot sizes influence the quality of treatment plans for non-small cell lung cancer (NSCLC) patients, considering tumor volume and respiratory motion.
- Results showed that single-field optimization (SFO) was adequate for 12 of the 20 patients, indicating a tendency for SFO plans to provide lower quality treatment compared to multi-field optimization (MFO) in addressing interplay effects while maintaining dosimetric requirements.
The increased radioresistence of healthy tissues when irradiated at very high dose rates (known as the Flash effect) is a radiobiological mechanism that is currently investigated to increase the therapeutic ratio of radiotherapy treatments. To maximize the benefits of the clinical application of Flash, a patient-specific balance between different properties of the dose distribution should be found, that is, Flash needs to be one of the variables considered in treatment planning. We investigated the Flash potential of three proton therapy planning and beam delivery techniques, each on a different anatomical region.
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