Publications by authors named "Anna Kocharyan"
Article Synopsis
- Inclusion body myositis (IBM) is a common inflammatory muscle disease in older adults that currently has no effective treatment and presents a mix of inflammatory and degenerative characteristics.
- Researchers used advanced sequencing techniques to analyze muscle biopsies from IBM patients, finding unique patterns of cellular changes compared to other muscle diseases and non-inflammatory muscles.
- Key findings reveal a loss of specific muscle fibers, increased immune cell presence, and markers of cell stress and protein degradation, highlighting potential mechanisms behind muscle degeneration in IBM and pointing to vulnerabilities in type 2 muscle fibers.
Background: Mechanical thrombectomy (MT) is the standard of care for patients with a stroke and large vessel occlusion. Clot composition is not routinely assessed in clinical practice as no specific diagnostic value is attributed to it, and MT is performed in a standardized 'non-personalized' approach. Whether different clot compositions are associated with intrinsic likelihoods of recanalization success or treatment outcome is unknown.
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