Two-step conversion of uridine and cytidine to variously C5-C functionalized analogs.

C5-substituted pyrimidine nucleosides are an important class of molecules that have practical use as biological probes and pharmaceuticals. Herein we report an operationally simple protocol for C5-functionalization of uridine and cytidine transformation of underexploited 5-trifluoromethyluridine or 5-trifluoromethylcytidine, respectively. The unique reactivity of the CF group in the aromatic ring allowed the direct incorporation of several distinct C5-C "carbon substituents": carboxyl, nitrile, ester, amide, and amidine.

Reconstructing GRACE-type time-variable gravity from the Swarm satellites.

The Gravity Recovery and Climate Experiment (GRACE) mission has enabled mass changes and transports in the hydrosphere, cryosphere and oceans to be quantified with unprecedented resolution. However, while this legacy is currently being continued with the GRACE Follow-On (GRACE-FO) mission there is a gap of 11 months between the end of GRACE and the start of GRACE-FO which must be addressed. Here we bridge the gap by combining time-variable, low-resolution gravity models derived from European Space Agency's Swarm satellites with the dominating spatial modes of mass variability obtained from GRACE.

An assessment of energy expenditure of soldiers serving in the Polish chemical units, performing training tasks in 2 types of personal chemical protective clothing - comparative studies.

Objectives: Individual protection against contamination is the kind of protection provided to persons in an environment contaminated with radioactive substances, and war toxic or biological agents, including the use of gas masks, and insulating or filtration skin protection agents. The aim of this work was to perform a comparative assessment of energy expenditure of chemical troop soldiers wearing L-2 insulating personal protective clothes (PPC) and FOO-1 filter-sorptive PPC during training in the training ground conditions. Surveys on the subjective assessment of comfort related to using the L-2 and FOO-1 PPC were carried out as well.

Effect of 3-year education in the Main Fire Service School on the fitness level of students.

Introduction And Objective: The aim of the study was to determine changes in the fitness level among students of the Main Fire Service School during 3-year's education.

Material And Methods: A total of 75 male and 5 female students took part in the study. Fitness level measurements were carried out before beginning the studies (Measurement 0) and after the 1st, 2nd and 3rd years at the school (Measurement 1, 2, 3).

Influence of protein deficient diet, vitamin B[sub]2[/sub] supplementation and physical training on serum composition of polyunsaturated fatty acids (PUFAs) in rats.

[b]Introduction[/b]. Prolonged shortages of protein in the diet significantly alter the composition and content of polyunsaturated fatty acids (PUFA) in tissues and body fluids. One of nutritional factors which may reduce negative effects of protein malnutrition might be vitamin B[sub]2[/sub] due to its influence on lipids metabolism.

Influence of Military Training and Standardized Nutrition in Military Unit on Soldiers' Nutritional Status and Physical Fitness.

Tomczak, A, Bertrandt, J, Kłos, A, and Kłos, K. Influence of military training and standardized nutrition in military unit on soldiers' nutritional status and physical fitness. J Strength Cond Res 30(10): 2774-2780, 2016-Despite suspension of conscription in Polish Army, trainings of soldiers are still carried out.

The influence of vitamin B12 supplementation on the level of white blood cells and lymphocytes phenotype in rats fed a low-protein diet.

Protein malnutrition has a negative effect on body composition and some blood parameters, especially in the young growing organism. One of nutritional factors which could protect against negative consequences of protein deficiency may be B group vitamins. The aim of the study was to investigate the effect of vitamin B12 supplementation on the immune system in rats fed a standard and a low-protein diet.

[Dressler syndrome following pulmonary embolism].

A case of a 73-year-old woman with fibrinous pericardial effusion which developed four weeks following severe pulmonary embolism. Clinical and echocardiographic data as well as an inclination to self-limited course were suggestive of Dressler syndrome diagnosis. Although there were no data that oral vitamin K antagonist use was involved in presented pericardial syndrome, pericardial effusion size required its temporary substitution by heparin.

[The assessment of nutritional status of the selected navy warship crew].

The aim of the work was the assessment of nutritional status of the ORP "PULASKI" frigate crew before long lasting training cruise. Crew of the warship consisting of 156 men, aged 22-42, underwent the nutritional status examination. The nutritional status was estimated based on the anthropometrical measurements.

Ephedrine-caffeine mixture in wet-cold stress.

Our investigations were aimed at studying the possibility of enhancement of homeostatic processes protecting against excessive body cooling by using thermogenic drugs. We studied the influence of ephedrine (1 mg/kg) and caffeine (2.5 mg/kg) mixture in males immersed in cold water (12 degrees C) on core temperature and plasma catecholamines, cortisol, energy substrates and chosen cognitive functions in subjects without or after previous submission to short cold acclimation procedure by five repeated brief cold-water immersions.

Polyunsaturated fatty acid (PUFA) changes in serum and liver of undernourished rats given dietary vitamin B6 supplementation.

The influence of vitamin B6 on linoleic (LA), alpha-linolenic (ALA), arachidonic (AA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid content in serum and liver of rats fed with protein-energy deficient diets for 90 d, was studied. To estimate the effect of dietary supplementation with vitamin B6 on the composition and level of fatty acids in the serum and liver of rats, two experiments were performed. In these experiments control rats were fed ad libitum semisynthetic isocaloric diets of 1,466.

Content of polyunsaturated fatty acids (PUFAs) in serum and liver of rats fed restricted diets supplemented with vitamins B2, B6 and folic acid.

The aim of study was to investigate an influence of nutritional deficiency and dietary addition of vit. B(2), B(6) and folic acid on PUFAs content in rats' serum and liver. Limitation of consumption full value diet to 50% of its previously determined daily consumption, enriched with m/a vitamins, significant decreased of linoleic (LA) and alpha-linolenic (ALA) acids as well as distinctly increased arachidonic (AA) and docosahexaenoic (DHA) acids content in serum in 30th day.

Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein.

The influence of vitamin B6 on fatty acids content in serum and liver of rats receiving low protein diets was studied. Addition of B6 decreased linoleic acid (LA) and increased alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) in serum of rats fed a protein-deficient diet (9% energy from proteins) for 3 months. Further restriction of dietary protein (4.

Effect of restricted feed intake and addition of vitamins B2 and B6 and folic Acid on the liver concentration of zinc and copper in rats.

The aim of the present study was to investigate the influence of nutritional deficiency and dietary addition of vitamins (B2, B6, and folate) on hepatic concentration of zinc and copper in rats. The experiment was performed on 260 growing male Wistar rats divided into 13 groups. Animals of 11 groups were fed isocaloric diets (14.