Publications by authors named "Anna Katharina Schlusche"
The development of the cerebral cortex relies on the controlled division of neural stem and progenitor cells. The requirement for precise spatiotemporal control of proliferation and cell fate places a high demand on the cell division machinery, and defective cell division can cause microcephaly and other brain malformations. Cell-extrinsic and -intrinsic factors govern the capacity of cortical progenitors to produce large numbers of neurons and glia within a short developmental time window.
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- - The study examines how splicing varies across different brain regions, focusing on the hippocampus and prefrontal cortex, using single-cell long-read sequencing to analyze 45 cell types at a specific developmental stage (postnatal day 7).
- - Researchers find that specific isoforms (variants of proteins) are expressed differently across brain regions, with most of these differences being linked to individual cell types, although some genes show influences from multiple cell types.
- - The approach combines spatial transcriptomics with long-read sequencing to create a detailed map of splicing patterns, enhancing our understanding of the brain's molecular and cellular complexity.