Publications by authors named "Anna Karoliny"
Article Synopsis
- The study assessed how being overweight or obese affects treatment response and relapse rates in children with inflammatory bowel disease (IBD) undergoing anti-TNF therapy.
- Conducted across 22 centers in 14 countries, it involved 637 children, with a comparison between those who were overweight/obese and those of normal weight.
- Findings showed no difference in loss of response to treatment initially, but overweight/obese children had higher relapse rates by the end of follow-up, indicating a potential long-term risk associated with their weight status.
Background: Real-world data of children with inflammatory bowel disease (IBD) after SARS-CoV-2 vaccination are needed.
Method: This prospective, observational study evaluate antibody kinetics of children with IBD 6 months after immunization with COVID-19 mRNA vaccine.
Results: 24 children with IBD were included, 22 received immunosuppressive treatment.
Article Synopsis
- The study investigates the characteristics and natural history of primary sclerosing cholangitis related to inflammatory bowel disease (PSC-IBD) diagnosed before age 6, referred to as very early onset IBD (VEO-IBD) compared to those diagnosed later.
- A total of 69 children were analyzed, finding that while most had ulcerative colitis, the VEO-PSC-IBD group had a higher incidence of PSC/autoimmune hepatitis overlap syndrome.
- Results suggest that VEO-PSC-IBD has similar initial characteristics to later-onset PSC-IBD but presents with a milder disease course, particularly regarding biliary complications.
Aims: Our aim was to measure the myoelectric modifications during gastric acid secretion along with the gastric pH in a rat model and to detect the gastrointestinal (GI) myoelectric changes in adolescents suffering from gastroesophageal reflux disease (GERD) along with the esophageal pH measurement.
Main Methods: In anesthetized rats, gastric acid secretion was initiated with intragastric histamine (50 mg/kg), and gastric pH, GI myoelectric activity and mechanical GI contractions were measured with intragastric pH electrode, subcutaneously implanted smooth muscle electromyography (SMEMG) electrodes and organ implanted strain gauges, respectively. In the clinical study, esophageal pH and GI myoelectric activity were measured in adolescents suffering from GERD with intraesophageal pH electrode and SMEMG electrodes placed on the abdominal surface, respectively.
Article Synopsis
- Ulcerative proctitis (UP) is a rare form of ulcerative colitis in children, with the study analyzing clinical features and outcomes of 196 diagnosed patients aged under 18 from 2016 to 2020.
- Most patients presented with symptoms like bloody stools and abdominal pain, and the study found that higher initial disease activity scores (PUCAI) were linked to worse outcomes, including the need for more aggressive treatments.
- By the end of the study, nearly half of the patients showed disease progression, and only a small percentage required colectomy, highlighting the challenges in managing UP in pediatric patients.
In the TRANS-IBD clinical trial, the outcomes are measured with selected validated questionnaires. Cross-cultural and age adaptations of the Self-Efficacy Scale for adolescents and young adults (IBD-SES), the Transition Readiness Assessment Questionnaire (TRAQ), and the Self-Management and Transition Readiness Questionnaire (STARx) were performed. Linguistic and cultural adaptation was carried out with the usage of reliability coefficients (Cronbach's α coefficients, Spearman's rank correlation), and with confirmatory factor analysis (CFA; root Mean Square Error of Approximation [RMSEA], Comparative Fit Index [CFI], and Tucker-Lewis Index [TLI]).
View Article and Find Full Text PDFDisease Activity Is Associated with Obesity in Newly Diagnosed Pediatric Patients with Ulcerative Colitis.
Int J Environ Res Public Health
December 2022
Malnutrition and inflammatory bowel disease (IBD) are interrelated conditions. Our aim was to assess the prevalence of malnutrition, to compare anthropometric parameters in the evaluation of nutritional status in pediatric IBD, and to investigate the association between anthropometric parameters and disease activity indices (AI). Pediatric patients with newly diagnosed IBD recorded between 2010 and 2016 in the Hungarian Pediatric IBD Registry were included in this cross-sectional study.
View Article and Find Full Text PDFAccording to the Porto criteria, upper endoscopy and ileocolonoscopy with histology for patients with pediatric inflammatory bowel disease (pIBD) are recommended with small bowel imaging (SBI). We aimed to evaluate the adherence to the Porto criteria and biopsy sampling practice and to evaluate the diagnostic yield of magnetic resonance enterography (MRE) first time in a nationwide pIBD inception cohort. Newly diagnosed pIBD cases (ages 0-18 years) are registered in the prospective, nationwide Hungarian Paediatric IBD Registry (HUPIR).
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