A multicolor and ratiometric fluorescent sensing platform for metal ions based on arene-metal-ion contact.

Despite continuous and active development of fluorescent metal-ion probes, their molecular design for ratiometric detection is restricted by the limited choice of available sensing mechanisms. Here we present a multicolor and ratiometric fluorescent sensing platform for metal ions based on the interaction between the metal ion and the aromatic ring of a fluorophore (arene-metal-ion, AM, coordination). Our molecular design provided the probes possessing a 1,9-bis(2'-pyridyl)-2,5,8-triazanonane as a flexible metal ion binding unit attached to a tricyclic fluorophore.

Rational Design of a Ratiometric Fluorescent Probe Based on Arene-Metal-Ion Contact for Endogenous Hydrogen Sulfide Detection in Living Cells.

We report the design and development of a fluorescent Cd(II) ion complex that is capable of the ratiometric detection of H2 S in living cells. This probe exploits the metal-ion-induced emission red shift resulting from direct contact between the aromatic ring of a fluorophore and a metal ion (i.e.

Aza-crown-ether-appended xanthene: selective ratiometric fluorescent probe for silver(I) ion based on arene-metal ion interaction.

In this Communication, we report on the development of a ratiometric fluorescent probe for silver(I) ions (Ag(I)) based on an arene-metal ion interaction. The probe selectively senses Ag(I) among various metal ions with a large-emission red shift under aqueous conditions, enabling the selective ratiometric detection of Ag(I). X-ray crystallography and NMR analyses reveal that Ag(I) comes into close contact with the fluorophore, which induces a large-emission red shift.