Selective Tumor Hypoxia Targeting Using M75 Antibody Conjugated Photothermally Active MoO Nanoparticles.

Photothermal therapy (PTT) mediated at the nanoscale has a unique advantage over currently used cancer treatments, by being spatially highly specific and minimally invasive. Although PTT combats traditional tumor treatment approaches, its clinical implementation has not yet been successful. The reasons for its disadvantage include an insufficient treatment efficiency or low tumor accumulation.

Targeting acute myeloid leukemia cells by CD33 receptor-specific MoS-based nanoconjugates.

Acute myeloid leukemia (AML) is a highly aggressive type of cancer caused by the uncontrolled proliferation of undifferentiated myeloblasts, affecting the bone marrow and blood. Systemic chemotherapy is considered the primary treatment strategy; unfortunately, healthy cells are also affected to a large extent, leading to severe side effects of this treatment. Targeted drug therapies are becoming increasingly popular in modern medicine, as they bypass normal tissues and cells.

A bioconjugated MoS based nanoplatform with increased binding efficiency to cancer cells.

We evaluate the application of surfactant-free liquid-phase exfoliated MoS2 nanosheets as a nanoplatform for a cancer detection and treatment system equipped with an antibody-antigen based recognition element. Employing antigen-antibody binding, we increased the probability of the endocytosis of MoS2 nanosheets into CAIX expressing cells by 30%. The nanosheets are functionalized with a specific antibody M75, which forms an antigen-antibody complex with CAIX.

Tailored Langmuir-Schaefer Deposition of Few-Layer MoS Nanosheet Films for Electronic Applications.

Few-layer MoS films stay at the forefront of current research of two-dimensional materials. At present, continuous MoS films are prepared by chemical vapor deposition (CVD) techniques. Herein, we present a cost-effective fabrication of the large-area spatially uniform films of few-layer MoS flakes using a modified Langmuir-Schaefer technique.