Publications by authors named "Anna K Tobiasch"
Res Pract Thromb Haemost
October 2024
Article Synopsis
- Sepsis-induced DIC is a serious condition with high morbidity and mortality, and factors like endothelial injury and extracellular vesicles (EV) are crucial in its development.
- The study examined the role of E-selectin, EV, tissue factor (TF), and tissue factor pathway inhibitor (TFPI) in identifying sepsis-induced coagulopathy by analyzing plasma samples from 87 sepsis patients.
- Findings indicated that while only TFPI and TF-PCA levels could effectively discriminate between patients with and without DIC, higher levels of TFPI specifically correlated with worsening DIC, suggesting that these markers could enhance diagnosis and treatment strategies in septic patients.
Article Synopsis
- Coagulopathy and organ dysfunctions are critical features of sepsis, and a study explored the role of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in septic shock patients.
- In the study, patients with septic shock had significantly higher levels of both TF and TFPI compared to healthy controls, with differences in their ratios possibly indicating disease severity and outcomes.
- The research findings suggest that a high TF/TFPI ratio is linked specifically to heart injury in septic patients, while elevated TFPI levels correlate with multiple organ dysfunctions and overall disease severity.
