Publications by authors named "Anna K Sutela"
Background: Studies have established that radiotherapy for childhood brain tumors (BTs) increases the risk of cerebrovascular disease (CVD); however, it is unclear how this will affect cognitive function. This study aimed to investigate the associations between radiotherapy-induced CVD, white matter hyperintensities (WMHs), and neurocognitive outcomes in adult survivors of childhood BTs.
Methods: In a cross-sectional setting, we conducted a national cohort that included 68 radiotherapy-treated survivors of childhood BTs after a median follow-up of 20 years.
Article Synopsis
- Childhood brain tumor survivors show significant signs of lumbar disc degeneration on MRI compared to age and sex-matched controls, indicating a higher risk of spine issues due to treatment.
- The study found higher Pfirrmann grades, more lumbar disc protrusions and extrusions, and a greater number of high-intensity zone lesions in the survivor group.
- Age at diagnosis and blood pressure were linked to the extent of intervertebral disc degeneration, with those diagnosed later in childhood experiencing less degeneration.
Background: Cranial radiotherapy may damage the cerebral vasculature. The aim of this study was to understand the prevalence and risk factors of cerebrovascular disease (CVD) and white matter hyperintensities (WMHs) in childhood brain tumors (CBT) survivors treated with radiotherapy.
Methods: Seventy CBT survivors who received radiotherapy were enrolled in a cross-sectional study at a median 20 years after radiotherapy cessation.
Childhood brain tumors (CBTs) and their treatment increase the risk of secondary neoplasms (SNs). We studied the incidence of secondary craniospinal tumors with magnetic resonance imaging (MRI) screening in a national cohort of survivors of CBT treated with radiotherapy, and we analyzed the Finnish Cancer Registry (FCR) data on SNs in survivors of CBT with radiotherapy registered as a part of the primary tumor treatment. A total of 73 survivors of CBT participated in the MRI study (mean follow-up of 19 ± 6.
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