Publications by authors named "Anna K Schroeder"
Aims/hypothesis: Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH) examined the acute response to metformin and glipizide in order to identify new pharmacogenetic associations for the response to common glucose-lowering medications in individuals at risk of type 2 diabetes.
Methods: One thousand participants at risk for type 2 diabetes from diverse ancestries underwent sequential glipizide and metformin challenges.
Article Synopsis
- The study aims to identify the glycemic and non-glycemic factors leading to diabetic retinopathy (DR) in individuals before and after developing type 2 diabetes (T2D).
- Fundus photography was utilized to assess DR in high-risk adults over a long follow-up period, revealing a notable prevalence of DR among those with T2D and factors like race, glucose levels, and weight influencing its occurrence.
- Key findings indicated that higher HbA1c levels significantly increased the risk of DR, while American Indian race was linked to a lower prevalence of the condition compared to non-Hispanic Whites.
Article Synopsis
- The study investigated whether reversing prediabetes to normal glucose regulation (NGR) lowers the risk of microvascular disease (MVD), alongside previously established benefits in reducing diabetes incidence.
- Participants who achieved NGR at least once during a study showed a lower prevalence of aggregate MVD, but this association faded when accounting for average A1C levels during follow-up.
- The findings suggest that achieving NGR is linked to reduced risk of specific MVDs like nephropathy and retinopathy, mainly due to lower blood sugar levels over time, indicating that risk factors for MVD may start even in the prediabetes range.