Publications by authors named "Anna J Voss"
Histone proteins affect gene expression through multiple mechanisms, including through exchange with histone variants. Recent findings link histone variants to neurological disorders, yet few are well studied in the brain. Most notably, widely expressed variants of H2B remain elusive.
View Article and Find Full Text PDFRegulation of histone proteins affects gene expression through multiple mechanisms including exchange with histone variants. However, widely expressed variants of H2B remain elusive. Recent findings link histone variants to neurological disorders, yet few are well studied in the brain.
View Article and Find Full Text PDFExtrinsic signaling between diverse cell types is crucial for nervous system development. Ligand binding is a key driver of developmental processes. Nevertheless, it remains a significant challenge to disentangle which and how extrinsic signals act cooperatively to affect changes in recipient cells.
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- Schizophrenia affects about 25% of individuals with 22q11.2 deletion syndrome (22q11.2DS), prompting a study to explore genetic factors that heighten this risk beyond the deletion itself.
- Researchers analyzed whole-genome sequencing data from 519 people with 22q11.2DS to compare genetic variants in those with schizophrenia to those without psychotic disorders, as well as assessing polygenic risk across broader populations.
- The study found that individuals with 22q11.2DS and schizophrenia had significantly higher polygenic risk scores for schizophrenia, highlighting that both the genetic deletion and other common risk factors play a crucial role in the increased likelihood of developing schizophrenia.